SS-OCTA versus ICGA: a comparison of detection efficiency for large choroidal vein patterns in AMD patients

IF 2.7 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI:10.1016/j.pdpdt.2025.105303

Nianjia Wang , Xindi Liu , Jiayi Wu , Xintong Xiang , Yujia Gao , Liang Yao , Xin Wang

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引用次数: 0

Abstract

Purpose

To compare the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) and indocyanine green angiography (ICGA) in visualizing and classifying large choroidal vein topography, and to evaluate the association between specific venous patterns and pachychoroid spectrum disease (PSD)-associated macular neovascularization (MNV).

Methods

This retrospective cross-sectional study included 222 eyes from 160 patients with neovascular age-related macular degeneration (nAMD). All participants underwent both SS-OCTA and ICGA imaging. Choroidal venous patterns were classified into four types based on ICGA venous phase images: watershed, anastomotic, upper thicker, and lower thicker. SS-OCTA images were processed and analyzed using Fiji software. Diagnostic agreement between modalities was assessed using Cohen’s Kappa. Logistic regression was used to evaluate the association between venous patterns and disease subtypes.

Results

SS-OCTA and ICGA showed almost perfect agreement in classifying choroidal venous patterns in discernible cases (unweighted Kappa = 0.978). Among 77 eyes where ICGA failed to provide a clear classification, SS-OCTA achieved a definitive diagnosis in 87.0 % (P < 0.001), with the anastomotic type being the most common. Furthermore, the watershed pattern was significantly more prevalent in non-PCV nAMD compared to PCV (29.8 % vs. 12.1 %, p = 0.002), suggesting distinct choroidal venous backgrounds between these subtypes.

Conclusion

SS-OCTA provides a reliable, non-invasive alternative to ICGA for visualizing and classifying large choroidal veins, with superior performance in cases obscured by hemorrhage or leakage. The distinct distribution of venous patterns across nAMD subtypes highlights the potential role of choroidal venous architecture in disease phenotyping and pathogenesis.

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SS-OCTA与ICGA：对AMD患者大脉络膜静脉形态检测效率的比较。

目的：比较扫描源光学相干断层血管造影（SS-OCTA）和吲哚菁绿血管造影（ICGA）对大脉络膜静脉形态的可视化和分类效果，并评价特定静脉形态与厚脉络膜谱病（PSD）相关黄斑新生血管（MNV）的关系。方法：回顾性横断面研究纳入160例新生血管性年龄相关性黄斑变性（nAMD）患者222只眼。所有参与者均行SS-OCTA和ICGA成像。基于ICGA静脉相图像将脉络膜静脉形态分为分水岭型、吻合口型、上厚型和下厚型四种。使用Fiji软件对SS-OCTA图像进行处理和分析。采用Cohen’s Kappa评估不同诊断模式的一致性。采用Logistic回归评估静脉形态与疾病亚型之间的关系。结果：SS-OCTA与ICGA对可识别病例脉络膜静脉形态的分类几乎完全一致（未加权Kappa = 0.978）。在ICGA不能提供明确分类的77只眼中，SS-OCTA获得明确诊断的比例为87.0% (P < 0.001)，其中吻合型最常见。此外，与PCV相比，分水岭模式在非PCV nAMD中更为普遍（29.8% vs. 12.1%, p = 0.002），表明这些亚型之间脉络膜静脉背景不同。结论：SS-OCTA为大脉络膜静脉的显像和分类提供了一种可靠的、无创的替代方法，在出血或渗漏模糊的情况下具有更好的表现。静脉模式在nAMD亚型中的独特分布突出了脉络膜静脉结构在疾病表型和发病机制中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.