Comparison of Contrast-Enhanced Ultrasound and CT/MRI in Transarterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy

IF 2.8 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2026-03-01 Epub Date: 2025-12-05 DOI:10.1016/j.ultrasmedbio.2025.11.007

Weixuan Kong , Leixin Qiu , Qing Li , Zerong Huang , Lingling Li , Ni He , Chuan Peng , Xu Han , Wei Zheng , Ruhai Zou

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引用次数: 0

Abstract

Objective

Early assessment of treatment response following locoregional therapy remains a challenge in managing hepatocellular carcinoma (HCC). Recent advancements in contrast-enhanced ultrasound (CEUS) have demonstrated significant potential in the early assessment of tumor viability. This study compared the evaluation capabilities of CEUS and CT/MRI in assessing treatment response to hepatic arterial infusion chemotherapy (HAIC) and transarterial chemoembolization (TACE).

Materials and methods

This study included patients who had received TACE or HAIC between 2010 and 2024. 1:1 propensity score matching was used to reduce confounding bias between the TACE and HAIC groups. A comparative analysis was carried out using pathological complete response of treated lesions as the reference standard to assess the diagnostic performance of CEUS and CT/MRI across different treatment strategies.

Results

A total of 154 patients with 167 observations were ultimately included. In the propensity score matching cohort, CEUS and CT/MRI demonstrated similar diagnostic performance, with no significant differences in sensitivity (96% vs 92%, p = 0.07) or specificity (67% vs 57%, p > 0.99). Additionally, CEUS showed comparable results between HAIC and TACE groups in both sensitivity (98% vs 94%, p = 0.61) and specificity (50% vs 77%, p = 0.35).

Conclusion

CEUS demonstrated no significant difference in diagnostic performance compared with CT/MRI in evaluating HCC treatment response to HAIC and TACE.

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超声造影与CT/MRI在经动脉化疗栓塞与肝动脉灌注化疗中的比较。

目的：早期评估局部治疗后的治疗反应仍然是治疗肝细胞癌（HCC）的一个挑战。对比增强超声（CEUS）的最新进展已经证明了在早期评估肿瘤生存能力方面的重大潜力。本研究比较了超声造影和CT/MRI在评估肝动脉输注化疗（HAIC）和经动脉化疗栓塞（TACE）治疗反应方面的评估能力。材料和方法：本研究纳入了2010年至2024年间接受TACE或HAIC的患者。采用1:1倾向评分匹配来减少TACE组和HAIC组之间的混杂偏倚。以治疗后病变病理完全缓解为参考标准，对比分析超声造影和CT/MRI在不同治疗策略下的诊断效果。结果：最终纳入154例患者167项观察。在倾向评分匹配队列中，CEUS和CT/MRI表现出相似的诊断性能，敏感性（96% vs 92%, p = 0.07）或特异性（67% vs 57%, p = 0.99）无显著差异。此外，CEUS在HAIC组和TACE组之间的敏感性（98% vs 94%, p = 0.61）和特异性（50% vs 77%, p = 0.35）均显示出可比性。结论：超声造影与CT/MRI比较，在评价HCC对HAIC和TACE治疗的疗效方面无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.