Lower Serum Magnesium Levels Are Associated With Erectile Dysfunction Severity: A Cross-Sectional Study

IF 1.3 4区医学 Q3 ANDROLOGY

Andrologia Pub Date : 2025-12-01 DOI:10.1155/and/2579155

Mesut Cilli, Kemal Turker Ulutas

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引用次数: 0

Abstract

Objective

Erectile dysfunction (ED) is a common condition closely associated with vascular health and endothelial function. This study aimed to evaluate the possible effects of magnesium (Mg) deficiency on ED by comparing serum Mg levels between patients diagnosed with ED and healthy individuals.

Methods

This retrospective cross-sectional study was conducted on male patients, who presented to the urology outpatient clinic between June 2022 and January 2023. The study included 126 patients diagnosed with ED (Group 1) and 115 individuals without ED complaints (Group 2). The severity of ED was classified according to IIEF-5 scores.

Results

Biochemical serum analyses revealed that the serum Mg levels of the ED group (Group 1, 1.99 ± 0.17) were significantly lower compared to the control group (Group 2, 2.11 ± 0.19, p < 0.001). Additionally, C-reactive protein (CRP) levels were significantly higher in the ED group than in the control group (p < 0.001). Receiver operating characteristic (ROC) analysis determined the best cut-off value for Mg levels in predicting ED as 1.84 mg/dL (area under the curve [AUC] = 0.515). Analysis of variance (ANOVA) test results indicated a significant difference in Mg levels among groups classified according to ED severity (p < 0.001).

Conclusion

This study demonstrated that serum Mg levels were significantly lower in patients with ED compared to the control group and that there is a significant association between Mg levels and ED severity. Although these findings suggest an association between lower Mg levels and ED, causal inferences cannot be made, and the ROC analysis showed only limited discriminative ability (AUC = 0.515). Further prospective and interventional studies are warranted to clarify this relationship.

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低血清镁水平与勃起功能障碍严重程度相关：一项横断面研究

目的勃起功能障碍是一种与血管健康和内皮功能密切相关的常见病。本研究旨在通过比较诊断为ED的患者和健康个体的血清Mg水平，评估镁（Mg）缺乏对ED的可能影响。方法对2022年6月至2023年1月在泌尿外科门诊就诊的男性患者进行回顾性横断面研究。该研究包括126名诊断为ED的患者（第一组）和115名无ED症状的患者（第二组）。根据IIEF-5评分对ED的严重程度进行分级。结果血清生化分析显示，ED组（1组，1.99±0.17）血清Mg水平显著低于对照组（2组，2.11±0.19,p < 0.001）。此外，ED组的c反应蛋白（CRP）水平显著高于对照组（p < 0.001）。受试者工作特征（ROC）分析确定Mg水平预测ED的最佳临界值为1.84 Mg /dL（曲线下面积[AUC] = 0.515）。方差分析（ANOVA）检验结果显示，根据ED严重程度分类的组间Mg水平存在显著差异（p < 0.001）。结论与对照组相比，ED患者血清Mg水平明显降低，且Mg水平与ED严重程度之间存在显著相关性。虽然这些发现表明低Mg水平与ED之间存在关联，但无法进行因果推论，ROC分析仅显示有限的判别能力（AUC = 0.515）。需要进一步的前瞻性和干预性研究来阐明这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Andrologia 医学-男科学

CiteScore

5.60

自引率

8.30%

发文量

292

审稿时长

6 months

期刊介绍： Andrologia provides an international forum for original papers on the current clinical, morphological, biochemical, and experimental status of organic male infertility and sexual disorders in men. The articles inform on the whole process of advances in andrology (including the aging male), from fundamental research to therapeutic developments worldwide. First published in 1969 and the first international journal of andrology, it is a well established journal in this expanding area of reproductive medicine.