Differences in muscle sympathetic nerve activity between patients with orthostatic hypertension and those with orthostatic normotensive hypertension

IF 2.7 4区医学 Q2 NEUROSCIENCES

Autonomic Neuroscience-Basic & Clinical Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI:10.1016/j.autneu.2025.103366

Tadayuki Hirai , Hisayoshi Murai , Hiroyuki Sugimoto , Yusuke Mukai , Hideki Tokuhisa , Tatsunori Ikeda , Daisuke Kobayashi , Shigeo Takata , Kenji Sakata , Soichiro Usui , Masayuki Takamura

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引用次数: 0

Abstract

Orthostatic hypertension (OrthoHT), an excessive pressor response to standing, increases cardiovascular risk; however, its relationship with sympathetic nerve activity is poorly understood. This study aimed to assess differences in muscle sympathetic nerve activity (MSNA) between patients with OrthoHT and those with orthostatic normotensive hypertension. We measured resting MSNA in seven patients with OrthoHT and 11 matched controls. The OrthoHT group exhibited significantly elevated MSNA burst frequency (38.4 ± 12.2 vs. 28.3 ± 5.7 bursts/min, P < 0.05) and burst incidence (61.1 ± 21.3 vs. 44.6 ± 11.1 bursts/100 heartbeats, P < 0.05). In conclusion, OrthoHT is strongly associated with sympathetic hyperactivity at rest, suggesting that this may be a key physiological mechanism contributing to the increased cardiovascular risk observed in these patients.

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直立性高血压与直立性血压正常者肌肉交感神经活动的差异

直立性高血压（OrthoHT），站立时过度的血压反应，增加心血管风险；然而，它与交感神经活动的关系尚不清楚。本研究的目的是评估肌肉交感神经活动（MSNA）的差异在矫形ht患者和直立性血压正常的高血压患者。我们测量了7名OrthoHT患者和11名匹配对照的静息MSNA。OrthoHT组的MSNA爆发频率（38.4±12.2次/min vs 28.3±5.7次/min， P < 0.05）和爆发发生率（61.1±21.3次vs 44.6±11.1次/100次心跳，P < 0.05）显著升高。总之，OrthoHT与静息时交感神经亢进密切相关，提示这可能是导致这些患者心血管风险增加的关键生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.