ZnO/curcumin nanobio-complex loaded bioactive multifunctional gelatin-PCL membranes for accelerated wound healing through enhanced angiogenesis

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2026-04-01 Epub Date: 2025-12-02 DOI:10.1016/j.bioadv.2025.214631

Md Yousuf Ali , Prayas Chakma Shanto , Myeongki Park , Ihho Park , Md Sowaib Ibne Mahbub , Md Abdullah Al Fahad , Ume Farwa , Byong-Taek Lee

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Abstract

Activation of early angiogenesis, establishment of antimicrobial protection, and maintenance of an optimal moist microenvironment are the crucial factors for accelerated and scar-free wound healing. To achieve this, we synthesized ZnO/curcumin nanobio-complex and loaded different contents (0 %, 0.1 %, 0.5 %, 1 %, 5 % and 10 %) into gelatin /PCL (Polycaprolactone) electrospun membranes (GP, GP/NC0.1, GP/NC0.5, GP/NC1, GP/NC5 and GP/NC10, respectively). The membranes exhibited reasonable degradation, excellent hydrophilicity, water vapour exchangeability, chemical stability, swelling behavior, along with good mechanical strength and sustained drug release. GP/NC0.1, GP/NC0.5, and GP/NC1 exhibited biocompatibility, progressive cell proliferation and migration over time, as well as a significant in vitro angiogenesis effect. In addition to antibacterial and antioxidant properties, the GP/NC1 membrane demonstrated superior in vivo wound regeneration, characterized by the thickest neoepidermal formation compared to the GP/NC0.5 and GP groups. Subsequent immunohistochemical staining results demonstrated excellent angiogenesis, characterized by the upregulation of angiogenesis markers CD34, VEGF (Vascular endothelial growth factor) and endothelial Nitric Oxide Synthase (eNOS). Therefore, it is proposed that the GP/NC1 membrane could serve as a promising scaffold for accelerated wound healing.

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氧化锌/姜黄素纳米生物复合物负载生物活性多功能明胶- pcl膜，通过增强血管生成加速伤口愈合

早期血管生成的激活、抗菌保护的建立和最佳湿润微环境的维持是加速和无疤痕伤口愈合的关键因素。为了实现这一目标，我们合成了ZnO/姜黄素纳米生物复合物，并在明胶/聚己内酯电纺膜（GP、GP/NC0.1、GP/NC0.5、GP/NC1、GP/NC5和GP/NC10）中分别负载了不同含量（0%、0.1%、0.5%、1%、5%和10%）。该膜具有良好的降解性能、良好的亲水性、水蒸气交换性、化学稳定性、溶胀性、良好的机械强度和药物缓释性能。GP/NC0.1、GP/NC0.5和GP/NC1表现出生物相容性、随时间推移的进行性细胞增殖和迁移，并具有显著的体外血管生成作用。除了抗菌和抗氧化性能外，GP/NC1膜在体内伤口再生方面表现优异，与GP/NC0.5和GP组相比，其新表皮形成最厚。随后的免疫组化染色结果显示血管生成良好，其特征是血管生成标志物CD34、血管内皮生长因子（VEGF）和内皮型一氧化氮合酶（eNOS）上调。因此，我们提出GP/NC1膜可以作为一种很有前途的加速伤口愈合的支架。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!