Synthesis and self-assembly behavior investigation of paclitaxel-riboflavin conjugates for targeted drug delivery to tumor cells

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI:10.1016/j.nanoso.2025.101588

Dmitry V. Beigulenko , Vladimir O. Orlov , Ekaterina S. Kazakova , Inna V. Zhezher , Aleksander S. Peregudov , Julia A. Malinovskaya , Konstantin A. Kochetkov

引用次数: 0

Abstract

Paclitaxel is one of the commonly used anticancer drugs, however it has two major drawbacks such as low solubility and selectivity towards tumor cells. A promising approach to mitigating these problems is the development of targeted paclitaxel delivery systems based on its conjugates, capable of self-assembly. Herein we present novel paclitaxel-riboflavin conjugates that form spherical nanoparticles, which can be simply prepared by nanoprecipitation technique. The nanostructures are characterized by narrow size distribution and colloidal stability. Such nanoparticles can be considered as potential delivery systems for paclitaxel.

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靶向给药肿瘤细胞紫杉醇-核黄素偶联物的合成及自组装行为研究

紫杉醇是常用的抗癌药物之一，但其对肿瘤细胞的溶解度和选择性较低。缓解这些问题的一个有希望的方法是基于其偶联物的靶向紫杉醇递送系统的发展，能够自组装。本文提出了一种新的紫杉醇-核黄素缀合物，它可以形成球形纳米颗粒，可以通过纳米沉淀法简单地制备。纳米结构具有尺寸分布窄、胶体稳定性好等特点。这种纳米颗粒可以被认为是紫杉醇的潜在递送系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .