Reference Intervals of Lateral Ventricles for Extremely Pre-Term Infants: Multicenter Cohort Research

IF 2.8 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2026-03-01 Epub Date: 2025-12-04 DOI:10.1016/j.ultrasmedbio.2025.11.009

Junyi Yan , Yang Gao , Liangyu Guo , Dongmei Liu , Yuqi Tan , Jingyi Lu , Qiufang Tian , Lingyu Yan , Rong Gao , Yulin Peng

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引用次数: 0

Abstract

Objective

To establish reference intervals and intervention cutoffs for lateral ventricles in extremely pre-mature infants.

Methods

This prospective study recruited neurologically healthy extremely pre-mature infants born or treated at two Chinese Grade 3A Hospitals between 2021 and 2024. Upon enrollment (U1), anterior horn width (AHW), ventricular index (VI) and thalamo-occipital distance (TOD) were measured to establish reference values and surgical intervention cutoffs. Four weeks later, the same indices were measured (U2). We analyzed the correlations between AHW, VI and TOD and independent variables in U1 data using multiple linear regressions and compared the time-varying trends of AHW, VI and TOD between U1 and U2 data via mixed linear models.

Results

A total of 353 extremely pre-mature infants were included. Special attention was paid to the 97th percentile and 4 mm above it, internationally regarded as upper reference limits and intervention cutoffs for post-hemorrhagic ventricular dilation, respectively. The AHW, VI and TOD were all positively correlated with birth weight (p values <0.05) and increased over time (p values <0.001).

Conclusion

The study presents reference values and intervention cutoffs for AHW, VI and TOD in extremely pre-mature infants and provides an extensive comparison of all available reference values.

查看原文本刊更多论文

极早产儿侧脑室参考间隔：多中心队列研究。

目的：建立极早产儿侧脑室的参考区间和干预截止点。方法：本前瞻性研究招募了2021年至2024年间在两家中国三甲医院出生或治疗的神经系统健康的极早产儿。入组后（U1）测量前角宽度（AHW）、心室指数（VI）和丘脑-枕部距离（TOD），以建立参考值和手术干预截止点。四周后，测量相同的指数（U2）。采用多元线性回归分析了U1数据中AHW、VI、TOD与自变量之间的相关性，并采用混合线性模型比较了U1与U2数据中AHW、VI、TOD的时变趋势。结果：共纳入极早产儿353例。特别注意的是第97百分位和4毫米以上，国际上分别认为这是出血性心室扩张的上参考界限和干预截止点。结论：本研究提出了极早产儿AHW、VI和TOD的参考值和干预截止值，并对所有可用参考值进行了广泛的比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.