Plasmatic biochemical changes in COVID-19: Relevant markers that reflect patient genotypic predisposal

IF 3.9 3区医学 Q3 IMMUNOLOGY

Microbial pathogenesis Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI:10.1016/j.micpath.2025.108225

Jeferson S. Ursulino , Eloiza L.L. Tanabe , Aldilane L.X. Marques , Elaine C.O. da Silva , Juliana G.C. Leal , Larissa S. Pinto , Edmilson R.R. Júnior , Luana K.C. Santos , Carolinne Sales-Marques , Jorg A.P.M. Coelho , Marcos V.S. Sales , Eduardo J.S. Fonseca , Thiago S. Fragoso , Emiliano O. Barreto , Alexandre U. Borbely , Ana C.R. Leite , Thiago M. Aquino

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引用次数: 0

Abstract

Background

The emergence of COVID-19 as a global health threat, particularly exacerbated in pre-existing chronic conditions, underscores the imperative for continuous exploration of biomarkers to enhance clinical management.

Methods

This study employs multidimensional techniques, analyzing COVID-19 and control blood samples through plasma NMR, Raman spectroscopy, and leukocyte SNP genotyping.

Results

NMR metabolomics identifies heightened levels of L-lactic acid, D-glucose, VLDL/LDL, L-glutamic acid, and 1-methyl-histidine in COVID-19, alongside reduced levels of L-alanine and L-histidine. ROC curves exhibit robust discriminatory power, affirming the model's efficacy in distinguishing COVID-19 from control samples. Raman spectroscopy unveils bands associated with molecular vibrations of amino acids, lipids, and carotenoids in COVID-19. SNP genotyping reveals the rs2070788-TMPRSS2 association with elevated COVID-19 risk and rs8259-CD147 association with protective effects.

Conclusions

Our findings provides a comprehensive investigation of acute COVID-19, highlighting novel biomarkers, particularly the correlation between 1-methyl-histidine levels and the TMPRSS2 GG + AG genotype.

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COVID-19血浆生化变化：反映患者基因型易感的相关标志物

背景：COVID-19作为全球健康威胁的出现，特别是在已有慢性疾病中加剧，强调了不断探索生物标志物以加强临床管理的必要性。方法：本研究采用多维技术，通过血浆核磁共振、拉曼光谱、白细胞SNP基因分型对COVID-19和对照血样进行分析。结果：核磁共振代谢组学发现，在COVID-19中，l-乳酸、d -葡萄糖、VLDL/LDL、l-谷氨酸和1-甲基组氨酸水平升高，l-丙氨酸和l-组氨酸水平降低。ROC曲线表现出稳健的区分能力，证实了该模型在区分COVID-19和对照样本方面的有效性。拉曼光谱揭示了与COVID-19中氨基酸、脂质和类胡萝卜素的分子振动相关的波段。SNP基因分型显示rs2070788-TMPRSS2与COVID-19风险升高相关，rs8259-CD147与保护作用相关。结论：我们的研究结果提供了对急性COVID-19的全面调查，突出了新的生物标志物，特别是1-甲基组氨酸水平与TMPRSS2 GG+AG基因型之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)