Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients

IF 2.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal plus : cardiology research and practice Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI:10.1016/j.ahjo.2025.100690

Katelyn A. Bruno , R. Scott Wright , Joshua Culberson , Mikolaj A. Wieczorek , David O. Hodge , Patrick W. Johnson , Yomary A. Jimenez , Emily R. Whelan , Jose M. Malavet , Kathryn F. Larson , Jonathon W. Senefeld , Chad C. Wiggins , Stephen A. Klassen , Jacob Ricci , Taimur Sher , Rickey E. Carter , Michael J. Joyner , DeLisa Fairweather , Allan S. Jaffe

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Abstract

Objective

To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age.

Methods

We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April–August 2020) of the COVID-19 pandemic.

Results

We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age.

Conclusion

These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups.

Clinical Trials registration number: NCT04338360

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心脏肌钙蛋白T升高预测住院COVID-19患者的死亡率

目的探讨心肌肌钙蛋白值对不同性别和年龄的COVID-19患者预后不良的预测作用。方法我们检测了1050名有hs-cTnT数据的重症住院COVID-19患者的高敏心肌肌钙蛋白T （hs-cTnT）水平，这些患者参加了第一波（2020年4月- 8月）COVID-19大流行期间恢复期血浆研究扩大准入计划。结果我们观察到住院的男性和女性COVID-19患者的hs-cTnT水平与死亡率之间存在连续关系。这一发现与性别和年龄无关。结论这些数据表明hs-cTnT在所有相关患者组中预测住院COVID-19患者死亡率的预后能力。临床试验注册号：NCT04338360

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