Exploratory analysis of B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) across migraine phases

IF 3.1 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2026-02-01 Epub Date: 2025-11-30 DOI:10.1016/j.jneuroim.2025.578833

Nisha Smithi , Pooja Singh , Swathika Rajendran , Harini Purushothaman , Ameena Bee , Vishnupriya Gurumoorthy Mani , Sowmiya Mari , Deepa Avadhani , Rajesh Kumar Gandhirajan , Murugesan Arumugam

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引用次数: 0

Abstract

Emerging evidence suggests that imbalanced T-cell activity and immune dysfunction may contribute to migraine pathogenesis. However, the specific immune pathways remain unclear, particularly the role of B cells. To explore B-cell–related mechanisms, this study focused on two key members of the tumor necrosis factor (TNF) family, namely B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL), which play critical roles in B-cell survival and regulation. This study examined BAFF and APRIL expression in peripheral blood samples from migraine patients during pre-ictal, ictal, and post-ictal phases (n = 9) and in healthy controls (n = 9). BAFF levels increased during the ictal phase (p = 0.011) and declined in the post-ictal phase, whereas APRIL remained consistently downregulated relative to controls. The divergent patterns of BAFF and APRIL reveal a novel B-cell–related immune signature that may contribute to migraine pathogenesis. These preliminary findings support further studies to confirm these patterns and investigate the functional role of the BAFF–APRIL pathway in migraine.

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b细胞活化因子（BAFF）和A增殖诱导配体（APRIL）在偏头痛期的探索性分析

新的证据表明，不平衡的t细胞活性和免疫功能障碍可能有助于偏头痛的发病。然而，具体的免疫途径仍不清楚，特别是B细胞的作用。为了探索b细胞相关机制，本研究重点关注肿瘤坏死因子（TNF）家族的两个关键成员，即b细胞活化因子（BAFF）和A增殖诱导配体（APRIL），它们在b细胞存活和调控中起着关键作用。本研究检测了偏头痛患者在发作前、发作期和发作后的外周血样本（n = 9）和健康对照（n = 9）中BAFF和APRIL的表达。BAFF水平在绝经期升高（p = 0.011），在绝经期后下降，而APRIL相对于对照组持续下调。BAFF和APRIL的不同模式揭示了一种新的b细胞相关免疫特征，可能有助于偏头痛的发病。这些初步发现支持进一步的研究来证实这些模式，并调查BAFF-APRIL通路在偏头痛中的功能作用。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.