Acinetobacter baumannii ventriculoperitoneal shunt infection in the pediatric population: Clinical assessment and microbiological profile

IF 2.5 Q1 Medicine

World Neurosurgery: X Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI:10.1016/j.wnsx.2025.100552

Amer A. Jaradat , Mohammed M. Barbarawi , Mohammed Jamous , Sultan M. Jarrar , Suleiman S. Daoud , Amjed Abdelal , Said Haddad , Reem Alazzam , Marah Bashyreh , Owais Ghammaz

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Abstract

Background

Ventriculoperitoneal (VP) shunt infections, notably when caused by Acinetobacter baumannii, present significant management challenges in pediatric neurosurgery due to antibiotic resistance. This study assesses clinical profiles, microbiological characteristics, treatment strategies, and outcomes of these infections.

Methods

A retrospective review at King Abdullah University Hospital, North Jordan, analyzed 27 pediatric cases of Acinetobacter baumannii VP shunt infections from 2013 to 2023. Data on demographics, clinical presentation, treatment strategies, and outcomes, including cerebrospinal fluid (CSF) clearance time and time to shunt re-insertion, morbidity, and mortality were evaluated.

Results

Colistin showed efficacy against multidrug-resistant strains, despite overall high resistance to conventional antibiotics. Infections predominantly occurred early post-surgery and an 11.1 % mortality rate was observed.

Conclusion

VP shunt infections caused by Acinetobacter baumannii significantly impact pediatric patients, emphasizing the need for early detection and the development of targeted treatment approaches. Colistin may offer a viable option against resistant strains, but prolonged hospitalization and mortality rates call for improved preventive measures.

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鲍曼不动杆菌脑室腹腔分流感染在儿科人群：临床评估和微生物谱

背景脑室-腹膜（VP）分流感染，特别是由鲍曼不动杆菌引起的感染，由于抗生素耐药性，在儿科神经外科中提出了重大的管理挑战。本研究评估了这些感染的临床概况、微生物学特征、治疗策略和结果。方法回顾性分析2013 - 2023年约旦北部阿卜杜拉国王大学医院27例鲍曼不动杆菌VP分流感染病例。统计数据、临床表现、治疗策略和结果，包括脑脊液（CSF）清除时间和分流器重新插入时间、发病率和死亡率进行了评估。结果粘菌素对多药耐药菌株有效，但对常规抗生素总体耐药较高。感染主要发生在术后早期，死亡率为11.1%。结论鲍曼不动杆菌引起的vp分流感染对儿科患者影响显著，强调早期发现和制定有针对性的治疗方法的必要性。粘菌素可能是对抗耐药菌株的可行选择，但长期住院治疗和死亡率要求改进预防措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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