Effect of Phytochemical-Mediated synthesis using Allium sativum, Zingiber officinale, and Carica papaya extracts on the Inductive heating characteristics of MnFe2O4 nanoparticles

IF 4.6 2区物理与天体物理 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Results in Physics Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI:10.1016/j.rinp.2025.108546

G. Nandhini, M.K. Shobana

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Abstract

The synergistic exploration of magnetic nanoparticles and bioactive plant extracts has yielded a groundbreaking cancer therapeutic modality, capitalizing on the potential of nanotechnology and phytochemistry to target and ablate malignant cells. This comprehensive investigation elucidates the impact of various plant extracts on the structural, magnetic, hyperthermic, and cytotoxic properties of MnFe₂O₄ nanoparticles. The structural analysis of the nanoparticles functionalized with plant extracts reveals the formation of a single-phase spinel structure and exhibits a spherical morphology. FTIR analysis confirms the incorporation of bioactive compounds by identifying specific functional groups that contribute to the stabilization and functionalization of the nanoparticles. The microscopic and macroscopic investigation of magnetic properties exhibits a high saturation magnetization of 47 emu/g, accompanied by an inherently low coercivity (∼14 Oe) and a relatively short transverse relaxation time of 3.18*10^-11 s. Below the biological threshold, Zingiber officinale extract with MnFe₂O₄ nanoparticles exhibits a high specific absorption rate of 329 W/g under an applied magnetic field. The cytotoxicity analysis of Allium sativum extract revealed a good selectivity index of 2.3 with a 37 μg/ml IC₅₀ value, illustrating anti-proliferation activity against A-549 cells. These findings highlight the importance of phytochemical functionalization in MnFe₂O₄ nanoparticle performance for magnetic hyperthermia applications, with potential implications for cancer treatment.

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葱、生姜和番木瓜提取物的植物化学合成对MnFe2O4纳米颗粒感应加热特性的影响

磁性纳米颗粒和生物活性植物提取物的协同探索已经产生了一种开创性的癌症治疗方式，利用纳米技术和植物化学的潜力来靶向和消融恶性细胞。这项全面的研究阐明了各种植物提取物对MnFe2O4纳米颗粒的结构、磁性、高温和细胞毒性的影响。植物提取物功能化纳米颗粒的结构分析表明，纳米颗粒形成了单相尖晶石结构，并呈现球形形态。FTIR分析通过识别有助于纳米颗粒稳定和功能化的特定官能团，证实了生物活性化合物的掺入。微观和宏观研究表明，该材料具有47 emu/g的高饱和磁化强度，固有的低矫顽力（~ 14 Oe）和相对较短的横向弛豫时间（3.18*10-11 s）。在低于生物阈值的条件下，含MnFe2O4纳米粒子的生姜提取物在外加磁场下的比吸收率高达329 W/g。结果表明，葱提取物对a -549细胞具有良好的选择性，选择性指数为2.3，IC50值为37 μg/ml，具有抑制a -549细胞增殖的活性。这些发现强调了MnFe2O4纳米颗粒在磁热疗应用中的植物化学功能化的重要性，对癌症治疗具有潜在的意义。

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来源期刊

Results in Physics MATERIALS SCIENCE, MULTIDISCIPLINARYPHYSIC-PHYSICS, MULTIDISCIPLINARY

CiteScore

8.70

自引率

9.40%

发文量

754

审稿时长

50 days

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