Emerging insights into cell differentiation: the role of N-glycosylation in differentiation-based cancer therapies

IF 3.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI:10.1016/j.carres.2025.109787

Tiangui Wu , Pengfei Ye , Junjie Yang , Yuhan Sun

引用次数: 0

Abstract

N-glycosylation is a dynamic post-translational modification that critically regulates cancer cell differentiation through modulating receptor signaling, cell adhesion, and plasticity. Aberrant N-glycosylation promotes dedifferentiation, drives EMT, and confers therapy resistance across malignancies. This review summarizes the role of N-glycosylation in determining lineage commitment and altering responses to differentiation therapies. Targeting the N-glycosylation apparatus can reprogram tumor cells toward differentiated phenotypes, potentiating the effects of agents such as ATRA and NaBu. Evidence from leukemia and solid tumors reveals the therapeutic potential of disrupting glycan-dependent cell fate decisions. Deciphering these “glycan codes” provides a framework for integrating glycosylation modifiers into precision differentiation therapies, offering novel strategies to overcome treatment resistance.

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细胞分化的新见解：n-糖基化在基于分化的癌症治疗中的作用

n -糖基化是一种动态的翻译后修饰，通过调节受体信号、细胞粘附和可塑性来关键地调节癌细胞分化。异常的n -糖基化促进去分化，驱动EMT，并赋予恶性肿瘤治疗抵抗。本文综述了n -糖基化在决定谱系承诺和改变分化治疗反应中的作用。靶向n -糖基化装置可以将肿瘤细胞重编程为分化表型，从而增强ATRA和NaBu等药物的作用。来自白血病和实体瘤的证据揭示了破坏聚糖依赖细胞命运决定的治疗潜力。破译这些“聚糖编码”为将糖基化修饰剂整合到精确分化治疗中提供了一个框架，为克服治疗耐药性提供了新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".