Effect of frequency on dual target deep brain stimulation

IF 3.4 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI:10.1016/j.clinph.2025.2111467

Rocio Rodriguez Capilla , Aislinn M. Hurley , Karthik Kumaravelu , Jennifer J. Peters , Hui-Jie Lee , Dennis A. Turner , Warren M. Grill , Stephen L. Schmidt

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引用次数: 0

Abstract

Background

Deep brain stimulation reduces the motor symptoms of Parkinson’s disease (PD). Dual target deep brain stimulation (DT DBS) may better reduce symptoms and minimize side effects than single target, but the optimal parameters of DT DBS are unknown.

Objective

To quantify the frequency response of DT DBS on bradykinesia and beta oscillations, and to explore intrahemispheric pulse delay shifts as a means to reduce total energy delivered.

Methods

We applied DT DBS using the Summit RC + S in six participants with PD, varying DBS frequency. We further examined the effects of frequency in a biophysical model.

Results

DT DBS at 50 Hz was effective at reducing bradykinesia, whereas increasing DT DBS frequency up to 125 Hz also led to significantly lower beta power. This frequency effect on beta power was replicated in a biophysical model. The model suggested that 22 Hz DT DBS, with an intrahemispheric delay of 40 ms, can reduce beta power by 87 %.

Conclusion

This exploratory study (n = 6) suggests that 125 Hz DT DBS best reduced bradykinesia. However, low frequency DBS with an appropriate intrahemispheric delay could also improve symptom relief.

Significance

Both 125 Hz and tailored low-frequency DT DBS may achieve equivalent symptomatic control of PD symptoms.

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频率对双靶深部脑刺激的影响

脑深部刺激可减轻帕金森病（PD）的运动症状。双靶点深部脑刺激（DT DBS）可能比单靶点更好地减轻症状和减少副作用，但DT DBS的最佳参数尚不清楚。目的量化DT DBS对运动迟缓和β振荡的频率响应，并探讨脑内脉冲延迟移位作为减少总能量传递的手段。方法采用Summit RC + S对6例PD患者进行不同DBS频率的DBS治疗。我们在生物物理模型中进一步研究了频率的影响。结果50 Hz的DBS能有效降低运动迟缓，而125 Hz的DBS频率也能显著降低β功率。这种频率对能量的影响在生物物理模型中得到了复制。该模型表明，22 Hz DT DBS，在半球内延迟40 ms的情况下，可以使β功率降低87%。结论探索性研究（n = 6）表明125 Hz DT DBS治疗运动迟缓效果最好。然而，适当的脑内延迟低频DBS也可以改善症状缓解。意义125 Hz和量身定制的低频DT DBS均可达到PD症状的等效症状控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.