Association of Interleukin-10 with iron profile in obese and overweight individuals

Q2 Medicine

Obesity Medicine Pub Date : 2026-01-01 Epub Date: 2025-11-27 DOI:10.1016/j.obmed.2025.100669

Kizeisile R. Hau, A.K. Roopa, V.M. Vinodhini, P. Renuka

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引用次数: 0

Abstract

Introduction

Obesity is associated with chronic low-grade inflammation that may alter iron metabolism. Interleukin-10 (IL-10), an anti-inflammatory cytokine, has been studied in obesity, but its relationship with iron remains unclear. This study aimed to evaluate the association of IL-10 with iron status in obese and overweight individuals.

Methods

Cross-sectional observational study was carried with 90 patients undergoing master health screening at SRM Medical College Hospital & Research Centre, Tamil Nadu. Subjects were categorized by BMI kg/m² as healthy controls (BMI 18.5–22.9 kg/m²), overweight (BMI 23–24.9 kg/m²) and obese group (BMI ≥25 kg/m²).

Results

We found out a significant lower values in IL-10 (p = 0.015), serum Iron (p = 0.020) and transferrin saturation (p = 0.005) among obese group compared to the normal and overweight groups but inverse relationship with BMI (p < 0.001) and serum hs-CRP levels (p < 0.001) was observed. IL-10 shows a negative correlation with BMI (r = −0.256, p = 0.016) and with hs-CRP (r = −0.235, p = 0.028). In addition, no significant correlation was observed between IL-10 and iron, Ferritin, TIBC, and TSAT.

Conclusion

IL-10 levels were not significantly associated with iron parameters in obese and overweight individuals, providing preliminary evidence from an Indian population and underscoring the need for larger and longitudinal studies.

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白细胞介素-10与肥胖和超重个体铁谱的关系

肥胖与可能改变铁代谢的慢性低度炎症有关。白细胞介素-10 （IL-10）是一种抗炎细胞因子，已被研究用于肥胖，但其与铁的关系尚不清楚。本研究旨在评估IL-10与肥胖和超重个体铁状态的关系。方法对泰米尔纳德邦SRM医学院附属医院及研究中心接受主健康筛查的90例患者进行横断面观察研究。按BMI kg/m2分为健康对照组（BMI 18.5 ~ 22.9 kg/m2）、超重组（BMI 23 ~ 24.9 kg/m2）和肥胖组（BMI≥25 kg/m2）。结果肥胖组IL-10 （p = 0.015）、血清铁（p = 0.020）和转铁蛋白饱和度（p = 0.005）均低于正常和超重组，与BMI （p < 0.001）和血清hs-CRP （p < 0.001）呈负相关。IL-10与BMI呈负相关（r = - 0.256, p = 0.016），与hs-CRP呈负相关（r = - 0.235, p = 0.028）。此外，IL-10与铁、铁蛋白、TIBC和TSAT之间无显著相关性。结论：il -10水平与肥胖和超重个体的铁参数无显著相关性，这为印度人群提供了初步证据，并强调需要进行更大规模的纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.