Burden and determinants of benign prostate hyperplasia in Africa: Systematic review and meta-analysis

IF 3 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI:10.1016/j.canep.2025.102972

Kedir Seid , Abel Tibebu Goshu , Sintayehu Samuel Lorato , Mitiku Desalegn , Kelemu Abebe Gelaw , Yohannes Godie Ashebir , Olyad Kuma Getahun , Gebeyehu Lakew , Mathewos Mekonnen Gemmechu , Tiruye Menshaw Tiruneh , Yibeltal Assefa Atalay , Amlaku Nigusie Yirsaw , Eyob Ketema Bogale , Natnael Atnafu Gebeyehu , Tewodros Shitemaw Tekoye , Genanew Kassie Getahun

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Abstract

Objective

To determine the prevalence and determinants of benign prostate hyperplasia in Africa via a meta-analysis.

Methods

This report was presented according to the Preferred Reporting Items for Systematic Review and Meta-Analyses checklist. Thirteen articles were searched via PubMed/MEDLINE, EMBASE, Scopus, Google Scholar, Science Direct, and African Journal Online. Data were extracted via Microsoft Excel and exported to STATA 17 for analysis. The data were analyzed via the random effects model. The heterogeneity of the studies was assessed by Cochran’s Q test and I² statistics. Publication bias was detected via funnel plots and Egger’s test.

Result

In 13 studies conducted in Africa, with a sample size of 5619 people between 2011 and 2024, the pooled prevalence of benign prostate hyperplasia was 44 % (95 % CI 31 %-57 %) in Africa. According to the subgroup analysis, the pooled prevalence was greater in studies published from 2011--2018 (56 % (95 % CI: 38--73)) than in those published from 2019--2024 (34 %). The pooled prevalence rates were also greater in those with sample sizes > 500 than in those with sample sizes < 500 (45 % vs 41 %). Family history of BPH (OR = 5.56; 95 % CI; 1.57, 9.55), difficulty in sexual activity (OR = 13.14; 95 % CI: 5.50, 20.77), use of traditional eye medication (OR = 2.27; 95 % CI: 1.68, 2.86), family history (OR = 4.93; 95 % CI: 3.13, 6.72) and inadequate sleeping time (OR = 2.90, 95 % CI = 2.25–3.55) were factors associated with benign prostate hyperplasia among adults.

Conclusions

The pooled prevalence of BPH among adults living in Africa was significant. Family history, difficulty in sexual activity and inadequate sleeping time were significantly associated with benign prostate hyperplasia. The greater burden of BPH across the country calls for efforts by health policy makers to pay attention to it.

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非洲良性前列腺增生的负担和决定因素：系统回顾和荟萃分析。

目的：通过荟萃分析确定非洲良性前列腺增生的患病率和决定因素。方法：本报告按照系统评价和荟萃分析首选报告项目清单提交。通过PubMed/MEDLINE、EMBASE、Scopus、b谷歌Scholar、Science Direct和African Journal Online检索了13篇文章。通过Microsoft Excel提取数据，导出到STATA 17进行分析。采用随机效应模型对数据进行分析。采用Cochran’s Q检验和I2统计量评估研究的异质性。通过漏斗图和Egger检验检测发表偏倚。结果：在非洲进行的13项研究中，2011年至2024年间样本量为5619人，非洲良性前列腺增生的总患病率为44 %（95 % CI 31 %-57 %）。根据亚组分析，2011- 2018年发表的研究（56 %(95 % CI: 38- 73)）的总患病率高于2019- 2024年发表的研究（34 %）。在样本量为> 500的人群中，总患病率也高于其他人群。结论：生活在非洲的成年人中，BPH的总患病率是显著的。家族史、性活动困难和睡眠不足与良性前列腺增生显著相关。BPH在全国范围内造成的更大负担要求卫生政策制定者努力予以关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.