Leveraging Artificial Intelligence for decision support in neonatal and pediatric pharmacotherapy: A scoping review

IF 2.9 3区医学 Q1 PEDIATRICS

Seminars in Fetal & Neonatal Medicine Pub Date : 2026-02-01 Epub Date: 2025-11-19 DOI:10.1016/j.siny.2025.101691

Luana Conte , Nunzia Decembrino , Cristina Arribas , Federico Cucci , Giorgio De Nunzio , Ilaria Amodeo , Genny Raffaeli , Roberta Leonardi , Donato Cascio , Felipe Garrido , Giacomo Cavallaro

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引用次数: 0

Abstract

The use of Artificial Intelligence (AI) has the potential to transform healthcare in part by enhancing the accuracy of drug dosing and improving patient safety. However, its use in neonatology and pediatrics has just been started, with limited research exploring its full potential. This scoping review systematically maps the literature on AI applications in pediatric and neonatal pharmacology, analyzing studies published between 2004 and 2024. Searches in databases including MEDLINE, Scopus, and IEEE Xplore identified 412 records, of which 33 met the inclusion criteria. These included neonates (n = 8) and older pediatric patients (n = 25), encompassing 58,864 patients and utilizing various Machine-Learning techniques. The use of AI has demonstrated significant potential for precision dosing, predicting drug efficacy, and decreasing the occurrence of adverse events. Despite these promising findings, however, more rigorous, large-scale studies are essential to validate the results. Future research should prioritize real-world applications and address integration barriers, ensuring safe and effective use of AI in neonatal and pediatric clinical practice.

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利用人工智能在新生儿和儿童药物治疗中的决策支持：范围综述。

人工智能（AI）的使用有可能通过提高药物剂量的准确性和改善患者安全来改变医疗保健。然而，它在新生儿和儿科的应用才刚刚开始，探索其全部潜力的研究有限。本综述系统地绘制了人工智能在儿科和新生儿药理学应用方面的文献，分析了2004年至2024年间发表的研究。在MEDLINE、Scopus和IEEE Xplore等数据库中检索到412条记录，其中33条符合纳入标准。其中包括新生儿（n = 8）和老年儿科患者（n = 25），共58,864名患者，并利用各种机器学习技术。人工智能的使用在精确给药、预测药物疗效和减少不良事件发生方面显示出巨大的潜力。尽管有这些有希望的发现，然而，更严格的，大规模的研究是必要的，以验证结果。未来的研究应优先考虑实际应用并解决整合障碍，确保人工智能在新生儿和儿科临床实践中安全有效地使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Fetal & Neonatal Medicine 医学-小儿科

CiteScore

6.40

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Fetal & Neonatal Medicine (formerly Seminars in Neonatology) is a bi-monthly journal which publishes topic-based issues, including current ''Hot Topics'' on the latest advances in fetal and neonatal medicine. The Journal is of interest to obstetricians and maternal-fetal medicine specialists. The Journal commissions review-based content covering current clinical opinion on the care and treatment of the pregnant patient and the neonate and draws on the necessary specialist knowledge, including that of the pediatric pulmonologist, the pediatric infectious disease specialist, the surgeon, as well as the general pediatrician and obstetrician. Each topic-based issue is edited by an authority in their field and contains 8-10 articles. Seminars in Fetal & Neonatal Medicine provides: • Coverage of major developments in neonatal care; • Value to practising neonatologists, consultant and trainee pediatricians, obstetricians, midwives and fetal medicine specialists wishing to extend their knowledge in this field; • Up-to-date information in an attractive and relevant format.