Perioperative acute kidney injury in dogs undergoing elective desexing surgery

IF 2.5 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2026-01-01 Epub Date: 2025-10-27 DOI:10.1016/j.vaa.2025.10.005

Christopher T. Quinn, Randi Rotne, Emily Dockray, Andrew Neil Walton

{"title":"Perioperative acute kidney injury in dogs undergoing elective desexing surgery","authors":"Christopher T. Quinn, Randi Rotne, Emily Dockray, Andrew Neil Walton","doi":"10.1016/j.vaa.2025.10.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To report the incidence of acute kidney injury (AKI) in dogs after elective desexing surgery.</div></div><div><h3>Study design</h3><div>Prospective observational clinical study.</div></div><div><h3>Animals</h3><div>A group of 165 (71 male and 94 female) dogs admitted for castration or ovariohysterectomy.</div></div><div><h3>Methods</h3><div>Inclusion criteria were normal physical examination findings and no history of cardiovascular or renal disease. Serum creatinine (sCr) was measured before anaesthesia, and 24 and 48 hours postoperatively. AKI was defined by an increase (> 26 μmol L<sup>–1</sup>) in sCr from preoperative to 24 or 48 hours postoperatively. Changes in mean sCr pre-to post-anaesthesia were compared using paired <em>t</em>-tests. Differences in variables were compared between dogs with and without AKI with Fisher’s exact test for categorical data and continuous data using <em>t</em>-test or Mann–Whitney <em>U</em> test. Multivariable logistic regression was used to assess the significance of potential risk factors identified by univariable comparisons between AKI and non-AKI cases.</div></div><div><h3>Results</h3><div>Mean ± standard deviation age and body weight were 2.1 ± 1.7 years and 20.3 ± 10 kg, respectively. Mean change in pre-sCr to 24 and 48 hours was –6.9 ± 32.8 and –0.2 ± 22.8 μmol L<sup>–1</sup>, respectively (<em>p</em> > 0.05). sCr increased > 26 μmol L<sup>–1</sup> in eight dogs at 24 hours and in an additional four dogs at 48 hours. Twelve dogs (7.3%) were classified with AKI: one grade 2 AKI (sCr 175 μmol L<sup>–1</sup>) and 11 as grade 1 (sCr increase > 26 μmol L<sup>–1</sup> but within reference range). In addition, four of these dogs had oliguria in the first 24 hours postoperatively. Hypotension occurred frequently (67.9%) and along with female sex was significantly associated with AKI.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Perioperative AKI may be a common complication of elective desexing surgery in dogs. Potential risk factors include hypotension and female sex.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 1","pages":"Article 101149"},"PeriodicalIF":2.5000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1467298725002545","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To report the incidence of acute kidney injury (AKI) in dogs after elective desexing surgery.

Study design

Prospective observational clinical study.

Animals

A group of 165 (71 male and 94 female) dogs admitted for castration or ovariohysterectomy.

Methods

Inclusion criteria were normal physical examination findings and no history of cardiovascular or renal disease. Serum creatinine (sCr) was measured before anaesthesia, and 24 and 48 hours postoperatively. AKI was defined by an increase (> 26 μmol L^–1) in sCr from preoperative to 24 or 48 hours postoperatively. Changes in mean sCr pre-to post-anaesthesia were compared using paired t-tests. Differences in variables were compared between dogs with and without AKI with Fisher’s exact test for categorical data and continuous data using t-test or Mann–Whitney U test. Multivariable logistic regression was used to assess the significance of potential risk factors identified by univariable comparisons between AKI and non-AKI cases.

Results

Mean ± standard deviation age and body weight were 2.1 ± 1.7 years and 20.3 ± 10 kg, respectively. Mean change in pre-sCr to 24 and 48 hours was –6.9 ± 32.8 and –0.2 ± 22.8 μmol L^–1, respectively (p > 0.05). sCr increased > 26 μmol L^–1 in eight dogs at 24 hours and in an additional four dogs at 48 hours. Twelve dogs (7.3%) were classified with AKI: one grade 2 AKI (sCr 175 μmol L^–1) and 11 as grade 1 (sCr increase > 26 μmol L^–1 but within reference range). In addition, four of these dogs had oliguria in the first 24 hours postoperatively. Hypotension occurred frequently (67.9%) and along with female sex was significantly associated with AKI.

Conclusions and clinical relevance

Perioperative AKI may be a common complication of elective desexing surgery in dogs. Potential risk factors include hypotension and female sex.

查看原文本刊更多论文

择期绝育手术犬围手术期急性肾损伤。

目的：报道犬择期绝育术后急性肾损伤（AKI）的发生率。研究设计：前瞻性观察性临床研究。动物：165只（71只公犬，94只母犬）接受阉割或卵巢子宫切除术。方法：纳入标准为体格检查正常，无心血管或肾脏疾病史。麻醉前及术后24、48小时测定血清肌酐（sCr）。AKI的定义是sCr从术前到术后24或48小时增加（> 26 μmol L-1）。使用配对t检验比较麻醉前和麻醉后平均sCr的变化。对有AKI和没有AKI的狗的变量差异进行比较，分类数据采用Fisher精确检验，连续数据采用t检验或Mann-Whitney U检验。采用多变量logistic回归评估AKI和非AKI病例之间通过单变量比较确定的潜在危险因素的重要性。结果：平均±标准差年龄为2.1±1.7岁，体重为20.3±10 kg。24h和48h前scr的平均变化分别为-6.9±32.8和-0.2±22.8 μmol L-1 （p < 0.05）。8只狗24小时sCr升高26 μmol L-1，另外4只狗48小时sCr升高26 μmol L-1。12只（7.3%）犬被分类为AKI: 1只为2级AKI (sCr 175 μmol L-1)， 11只为1级AKI （sCr升高26 μmol L-1，但在参考范围内）。此外，其中4只狗在术后24小时内出现少尿。低血压频繁发生（67.9%），且女性与AKI显著相关。结论及临床意义：围手术期AKI可能是犬选择性绝育手术的常见并发症。潜在的危险因素包括低血压和女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.