The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice.

IF 3.4 2区 医学 Q1 DERMATOLOGY
Mycoses Pub Date : 2025-12-01 DOI:10.1111/myc.70135
O A Cornely, M Bassetti, C Garcia-Vidal, M Hoenigl, J Maertens, I Martin-Loeches, J P Mira, P L White
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引用次数: 0

Abstract

Invasive candidiasis is a life-threatening infection associated with high morbidity, mortality and healthcare costs in both general and critical care settings. Timely diagnosis and adequate antifungal treatment are essential to improving patient outcomes and limiting unnecessary use of healthcare resources. This review explores the relationship between early Candida clearance with antifungal therapy, clinical outcomes, resistance patterns and economic impact. It also evaluates the role of diagnostic markers in facilitating early and accurate identification of candidaemia, enabling more precise and effective clinical management. Special attention is given to the challenges of managing candidaemia in critically ill and neutropenic patients, highlighting the need for tailored and timely interventions in these vulnerable populations.

Abstract Image

Abstract Image

单纯念珠菌血症早期真菌学清除的重要性及其对临床实践的意义。
侵袭性念珠菌病是一种危及生命的感染,在普通和重症监护环境中具有高发病率、高死亡率和高医疗费用。及时诊断和充分的抗真菌治疗对于改善患者预后和限制不必要的医疗资源使用至关重要。这篇综述探讨了早期念珠菌清除与抗真菌治疗、临床结果、耐药性模式和经济影响之间的关系。它还评估了诊断标志物在促进早期和准确识别念珠菌血症方面的作用,从而实现更精确和有效的临床管理。特别关注在危重症患者和中性粒细胞减少患者中管理念珠菌血症的挑战,强调需要在这些脆弱人群中采取有针对性和及时的干预措施。
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来源期刊
Mycoses
Mycoses 医学-皮肤病学
CiteScore
10.00
自引率
8.20%
发文量
143
审稿时长
6-12 weeks
期刊介绍: The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi. Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.
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