Synergistic interaction between tuberculosis and depression: Changes in miRNA expression

IF 3.9 3区医学 Q3 IMMUNOLOGY

Microbial pathogenesis Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI:10.1016/j.micpath.2025.108211

Kevser Elçi , Necmiye Canacankatan , Cem Yalaza , Mukadder Çalıkoğlu , Semra Erdoğan , Gönül Aslan

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引用次数: 0

Abstract

Aim

Depression in TB patients results in non-adherence to anti-TB treatment, prolonged infectiousness, drug resistance and constitutes a significant obstacle to the elimination of TB. Understanding and addressing the social and biological complexities of TB is critical to controlling TB. In this study, the expression levels of miR-128–3p, miR-34a-5p, miR-223–3p, miR-221–3p, miR-24–3p, miR-107, miR-134–5p, miR-135a and miR-1202 which are associated with Depression (DP) pathology, were investigated in active Tuberculosis (TB), patients in order to evaluate the synergy between TB and DP.

Method

The study was carried out with 2 groups: TB Patient Group and Control Group. Expression levels of miRNAs were detected by Real-Time PCR method.

Results

It was determined that miR-128–3p, miR-34a-5p, miR-223–3p, miR-221–3p, miR-24–3p, miR-107, miR-134–5p and miR-135a expression levels in the TB Patient Group showed a statistically significant increase compared to the Control Group (p < 0.05). There was no difference between the groups in miR-1202 levels (p = 0.169).

Conclusion

The fact that miR-128–3p, miR-34a-5p, miR-223–3p, miR-221–3p and miR-24–3p, whose expressions were detected to increase in DP patients in previous studies, were also found to be increased in TB patients in this study, suggests that the miRNAs mentioned may be effective in the synergy between TB and DP. In addition, miR-24–3p, miR-107, miR-134–5p and miR-135a, whose expression was increased in TB patients in this study, can be considered as new biomarker candidates for TB.

查看原文本刊更多论文

结核病和抑郁症的协同作用：miRNA表达的变化。

目的：结核病患者的抑郁症导致抗结核治疗不坚持、传染性延长、耐药，并构成消除结核病的重大障碍。了解和处理结核病的社会和生物学复杂性对控制结核病至关重要。本研究通过对活动性结核（TB）患者中与抑郁（DP）病理相关的miR-128-3p、miR-34a-5p、miR-223-3p、miR-221-3p、miR-24-3p、miR-107、miR-134-5p、miR-135a和miR-1202的表达水平进行研究，以评价结核与DP的协同作用。方法：研究分为两组：结核患者组和对照组。采用Real-Time PCR法检测mirna的表达水平。结果：测定结核患者组miR-128-3p、miR-34a-5p、miR-223-3p、miR-221-3p、miR-24-3p、miR-107、miR-134-5p、miR-135a的表达水平较对照组有统计学意义升高(p)。miR-128-3p、miR-34a-5p、miR-223-3p、miR-221-3p和miR-24-3p在以往的研究中在DP患者中表达增加，在本研究中也发现在TB患者中表达增加，提示上述mirna可能在TB与DP的协同作用中有效。此外，miR-24-3p、miR-107、miR-134-5p和miR-135a在本研究中结核患者中表达升高，可以考虑作为新的结核生物标志物候选物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)