Anti-Parietal Cell Antibodies Show Differential Associations With Stomach Cancer by Site and Helicobacter pylori Status

IF 4.6 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2025-12-04 DOI:10.1111/hel.70093

Harindra Jayasekara, Julie K. Bassett, Howard Ho-Fung Tang, Yang Peng, Helen Tsimiklis, Robert L. O'Reilly, Brigid M. Lynch, Robert J. MacInnis, Graham G. Giles, Melissa C. Southey, Roger L. Milne, M. Constanza Camargo

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引用次数: 0

Abstract

Background

Autoimmune gastritis poses a risk for stomach cancer. However, its role relative to Helicobacter pylori-associated gastritis is uncertain. We assessed whether the associations between anti-parietal cell antibody (APCA) seropositivity and the risk of stomach cancer and its anatomical subtypes were modified by H. pylori infection.

Materials and Methods

A total of 244 incident gastric adenocarcinoma cases were identified from the Melbourne Collaborative Cohort Study (N = 41,513) and matched with 448 cancer-free controls using incidence density sampling with age as the time scale, matching on sex, year of birth, and country of birth. IgG antibodies against parietal cells and H. pylori were analyzed using commercially available ELISA kits. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.

Results

Seropositivity for APCA was 21% for controls and 24% for cases (28% cardia, 23% non-cardia), while seropositivity for H. pylori was 62% for controls and 76% for cases (55% cardia, 81% non-cardia). The following ORs were observed for total, cardia, and non-cardia cancers in relation to APCA seropositivity: 1.21 (95% CI: 0.84–1.76), 1.99 (0.84–4.73), and 1.09 (0.71–1.66), respectively. Stronger associations were observed for cardia cancer in H. pylori-seropositive individuals (ORs, 3.60 [95% CI: 1.07–12.12] vs. 0.93 [0.24–3.57] for H. pylori-seronegative individuals; p_interaction = 0.15) and for non-cardia cancer in H. pylori-seronegative individuals (ORs, 2.56 [1.02–6.40] vs. 0.93 [0.56–1.54] for H. pylori-seropositive individuals; p_interaction = 0.06).

Conclusions

Our findings suggest a more complex association between autoimmune gastritis and the risk of stomach cancer. They also highlight the importance of early detection of autoimmune gastritis in stomach cancer prevention.

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抗壁细胞抗体显示胃癌与部位和幽门螺杆菌状态的差异相关。

背景：自身免疫性胃炎可导致胃癌。然而，其在幽门螺杆菌相关性胃炎中的作用尚不确定。我们评估了抗壁细胞抗体（APCA）血清阳性与胃癌及其解剖亚型风险之间的关系是否被幽门螺杆菌感染所改变。材料和方法：采用以年龄为时间尺度、性别、出生年份和出生国家进行匹配的发病率密度抽样，从墨尔本协同队列研究（N = 41,513）中共确定244例胃腺癌病例，并与448例无癌对照进行匹配。采用市售ELISA试剂盒检测抗壁细胞和幽门螺杆菌IgG抗体。校正优势比（ORs）和95%置信区间（ci）使用条件逻辑回归估计。结果：APCA血清阳性为对照组21%，病例24%（贲门28%，非贲门23%），幽门螺杆菌血清阳性为对照组62%，病例76%（贲门55%，非贲门81%）。总癌、贲门癌和非贲门癌与APCA血清阳性相关的or分别为1.21 （95% CI: 0.84-1.76）、1.99（0.84-4.73）和1.09（0.71-1.66）。幽门螺杆菌血清阳性个体与贲门癌的相关性更强（or, 3.60 [95% CI: 1.07-12.12] vs. 0.93 [0.24-3.57]， p交互作用= 0.15），幽门螺杆菌血清阴性个体与非贲门癌的相关性更强（or, 2.56 [1.02-6.40] vs. 0.93 [0.56-1.54]， p交互作用= 0.06）。结论：我们的研究结果表明，自身免疫性胃炎与胃癌风险之间存在更复杂的关联。他们还强调了早期发现自身免疫性胃炎对胃癌预防的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.