Synchronous Macular Amyloidosis and Brachioradialis Pruritus Successfully Treated With Gabapentin.

Abstract

Brachioradial pruritus (BRP) and macular amyloidosis (MA) are distinct dermatological conditions that have rarely been reported together. BRP is a neuropathic pruritus affecting the lateral forearm, whereas MA presents as hyperpigmented patches caused by amyloid deposition in the dermis. We report the first case of synchronous MA and BRP in a 45-year-old woman who presented with severe pruritus in the brachioradialis distribution, concurrent with hyperpigmented patches characteristic of MA. Cervical spine imaging revealed moderate-to-severe multilevel degenerative changes. The patient was successfully treated with gabapentin 200 mg daily, with significant improvement in both conditions. This case highlights the first reported synchronous presentation of MA and BRP and suggests potential shared pathophysiological mechanisms. The favorable dual therapeutic response to gabapentin provides new insights into management strategies for concurrent presentations of these conditions.