Role of lipid peroxidation and chronic inflammation in development of post-thrombotic syndrome.

IF 3.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2026-06-01 Epub Date: 2025-12-05 DOI:10.1080/13813455.2025.2592017

Hanjun Wang, Jinhua Jiang

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引用次数: 0

Abstract

Post-thrombotic syndrome (PTS), a chronic complication of deep vein thrombosis, causes pain, swelling, and ulcers, impairing quality of life. This study explores the role of lipid peroxidation and chronic inflammation in PTS. Oxidative stress and chronic inflammation damage the endothelium, increase venous pressure, and induce fibrosis, driving PTS progression. A biomarker-based ELISA approach is proposed to measure plasma lipid peroxidation products (e.g. MDA) and pro-inflammatory cytokines (e.g. IL-6, TNF-α). This method detects early biochemical changes in post-DVT patients and tracks PTS risk. Elevated oxidative and inflammatory markers are strongly linked to PTS, supporting their use as diagnostic and therapeutic targets. Screening may improve prediction (98.7%), prevention (97.3%), and management (99.4%), while reducing MDA (95.6%), IL-6 (93.4%), and TNF-α (97.45%). Observational NHS data support symptom-biomarker correlations. Preliminary values for MDA (14.3 ± 4.1 nmol/mL), IL-6 (2.3 ± 1.1 pg/mL), and TNF-α (1.5 ± 0.7 pg/mL) are included to clearly present and support the research hypothesis.

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脂质过氧化和慢性炎症在血栓形成后综合征发展中的作用。

血栓形成后综合征（PTS）是深静脉血栓形成的慢性并发症，引起疼痛、肿胀和溃疡，影响生活质量。本研究探讨脂质过氧化和慢性炎症在PTS中的作用。氧化应激和慢性炎症损伤内皮，增加静脉压，诱导纤维化，推动PTS进展。提出了一种基于生物标志物的ELISA方法来测量血浆脂质过氧化产物（如MDA）和促炎细胞因子（如IL-6， TNF-α）。该方法可检测dvt后患者早期生化变化，追踪PTS风险。氧化和炎症标志物升高与PTS密切相关，支持其作为诊断和治疗靶点。筛查可改善预测（98.7%）、预防（97.3%）和管理（99.4%），同时降低MDA（95.6%）、IL-6（93.4%）和TNF-α(97.45%)。观察性NHS数据支持症状与生物标志物的相关性。MDA(14.3±4.1 nmol/mL), IL-6（2.3±1.1 pg/mL）和TNF-α（1.5±0.7 pg/mL）的初步值被纳入，以清楚地表达和支持研究假设。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.