Therapeutic approaches in adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of current evidence

IF 9.8 1区 医学 Q1 IMMUNOLOGY
Autoimmunity reviews Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI:10.1016/j.autrev.2025.103970
Jakob Stögbauer , Victoria Schegerer , Clemens Klein , Marc Pawlitzki , Sven G. Meuth , Orhan Aktas , Sergiu Groppa , Mathias Fousse
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引用次数: 0

Abstract

Recent years have seen a considerable increase in knowledge pertaining to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Nevertheless, a noteworthy degree of uncertainty remains within the neurological community, primarily due to the often highly heterogeneous nature of the disease and the absence of approved long-term treatment options. In this article, we undertake a comprehensive review of the various treatment strategies and drug options available for the pharmacological treatment of acute attacks and relapses in MOGAD.
髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)成人的治疗方法:当前证据综述
近年来,有关髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)的知识有了相当大的增加。然而,神经学界仍然存在很大程度的不确定性,这主要是由于该疾病往往具有高度异质性,并且缺乏经批准的长期治疗方案。在这篇文章中,我们对MOGAD急性发作和复发的各种治疗策略和药物选择进行了全面的回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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