Recent advances in numerical simulation of magnetically guided drug delivery systems and applications

IF 21 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI:10.1016/j.addr.2025.115745

Zhenyang Xu , Tayebeh Mousavi , Xiaoli Liu , Anita Ahmadi Birjandi , Maya Thanou , Haiming Fan , Mark Ainslie

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Abstract

Magnetically guided drug delivery (MGDD) employs magnetic forces acting on magnetically responsive drug delivery systems (DDS) to direct therapeutic agents toward diseased regions, thereby enhancing local drug accumulation while minimising systemic side effects. Numerical simulation, grounded in the physical principles governing MGDD, provides an efficient computational framework for modelling and visualising these processes, thereby accelerating progress in MGDD research. This review comprehensively summarises recent advances in the application of numerical simulation to MGDD, including magnet design and analysis, multiscale modelling of DDS transport processes at macroscopic, mesoscopic, and microscopic scales, and DDS design and evaluation. In addition, the integration of optimisation algorithms and artificial intelligence (AI) with numerical simulation for MGDD is discussed. Finally, future perspectives are presented, emphasising the development of high-fidelity, multiscale, and AI-driven simulation frameworks to accelerate clinical translation toward personalised, efficient MGDD-based therapeutic systems.

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磁导给药系统数值模拟及其应用的最新进展

磁导给药（MGDD）利用磁力作用于磁响应药物给药系统（DDS），将治疗剂导向病变区域，从而增强局部药物积累，同时最大限度地减少全身副作用。数值模拟以控制MGDD的物理原理为基础，为这些过程的建模和可视化提供了有效的计算框架，从而加速了MGDD研究的进展。本文综述了近年来数值模拟技术在磁体设计与分析、DDS输运过程宏观、介观和微观多尺度模拟、DDS设计与评价等方面的研究进展。此外，还讨论了优化算法和人工智能（AI）与MGDD数值模拟的集成。最后，提出了未来的展望，强调高保真、多尺度和人工智能驱动的模拟框架的发展，以加速向个性化、高效的基于mddd的治疗系统的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.