Is psoriatic arthritis a dissemination of cutaneous psoriatic TRM cells? Role of tissue-resident memory T cells (TRM) in psoriatic disease

IF 5.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI:10.1016/j.coi.2025.102702

Siba P Raychaudhuri , Smriti K Raychaudhuri

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Abstract

Tissue resident memory T cells (TRM) cells are a recently defined subtype of nonrecirculating memory T cells with longevity and protective functions in peripheral tissues. The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity with respect to site-specific immune response. For frontline defense against infections, TRM cells are essential. Accumulating evidence also implies that TRM cells are likely to contribute to the relapse and chronicity in autoimmune diseases, including psoriatic disease. A number of studies have shown the relationship between the pathogenesis of psoriasis and skin-resident memory T cells. Here, we discussed recent insights into the generation, homing, survival, and retention of TRM cells and shared our perspectives on the functions of TRM cells in the recurrence of psoriasis and psoriatic arthritis (PsA). This review summarizes the role of TRM cells in the pathology of psoriasis/PsA, with a view to develop potential novel therapies and therapeutic targets.

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银屑病关节炎是皮肤银屑病TRM细胞的扩散吗？组织常驻记忆T细胞（TRM）在银屑病中的作用

组织常驻记忆T细胞（Tissue resident memory T cells， TRM）是最近发现的一种非循环记忆T细胞亚型，在外周组织中具有长寿和保护功能。驻留在不同组织中的T细胞的发现改变了我们对适应性免疫的理解，即位点特异性免疫反应。对于抵抗感染的一线防御，TRM细胞是必不可少的。越来越多的证据也表明，TRM细胞可能导致自身免疫性疾病（包括银屑病）的复发和慢性。许多研究表明银屑病的发病机制与皮肤驻留记忆T细胞有关。在这里，我们讨论了TRM细胞的产生、归巢、存活和保留的最新见解，并分享了我们对TRM细胞在银屑病和银屑病关节炎（PsA）复发中的功能的看法。本文综述了TRM细胞在银屑病/PsA病理中的作用，以期开发潜在的新疗法和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.