Gender Differences in Patients with Advanced Heart Failure: A Secondary Data Analysis of the ENABLE CHF-PC Randomized Clinical Trial.

IF 1.3 Q4 HEALTH CARE SCIENCES & SERVICES

Palliative medicine reports Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI:10.1177/26892820251396380

Lindsay Aaron-Wade, Rachel Wells, Andres Azuero, Shena Gazaway, J Nicholas Odom, Marie Bakitas, Deborah Ejem

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Abstract

Background: Women appear to be underrepresented in heart failure and palliative care research. Given this underrepresentation, their unique characteristics, needs, and outcomes require further investigation.

Methods: A secondary analysis of baseline data of the Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcare for Patients and Caregivers study, a randomized clinical trial of Deep South patients ≥50 years of age with advanced HF. Differences in sociodemographics and measures of quality of life and mood between female and male patients were examined using bivariate tests and effect-size measures.

Results: Statistically significant gender differences were observed with females reporting poorer quality of life-The Kansas City Cardiomyopathy Measure (49.55 ± 20.04 vs. 55.37 ± 21.52, d = 0.28, p-adj = 0.01), Patient-Reported Outcome Measurement Information System (PROMIS) Global Mental Health (44 ± 8.02 vs. 46.53 ± 9.01, d = 0.30, p-adj = 0.007), and PROMIS Global Physical Health (37.37 ± 7.65 vs. 39.2 ± 8.20, d = 0.23, p-adj = 0.034) and Hospital Anxiety and Depression Scale anxiety (6.9 ± 4.38 vs. 4.72 ± 3.89, d = 0.53, p-adj = 0.003) compared with men at baseline.

Conclusion: Further investigation of gender differences is necessary to improve outcomes and inform the refinement of PC-HF interventions for females.

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晚期心力衰竭患者的性别差异：ENABLE CHF-PC随机临床试验的二次数据分析

背景：女性在心力衰竭和姑息治疗研究中的代表性似乎不足。鉴于这种代表性不足，他们的独特特征、需求和结果需要进一步调查。方法：对教育、培养、建议、生命结束前患者和护理人员综合心脏护理研究的基线数据进行二次分析，这是一项随机临床试验，研究对象为≥50岁的美国深南部晚期HF患者。使用双变量测试和效应量测量来检查男女患者在社会人口统计学和生活质量和情绪测量方面的差异。结果:在堪萨斯城心肌病量表（49.55±20.04比55.37±21.52,d = 0.28, p-adj = 0.01）、患者报告结果测量信息系统（PROMIS）全球心理健康量表（44±8.02比46.53±9.01,d = 0.30, p-adj = 0.007）和PROMIS全球身体健康量表（37.37±7.65比39.2±8.20,d = 0.23）中，女性报告的生活质量较差，性别差异具有统计学意义。p-adj = 0.034)和医院焦虑和抑郁量表焦虑（6.9±4.38比4.72±3.89,d = 0.53, p-adj = 0.003）与基线时的男性相比。结论：有必要进一步研究性别差异，以改善预后，并为女性PC-HF干预措施的完善提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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