Hui-Ting Goh, Jill C Stewart, Yu-Chen Chung, Kevin Becker, Ty Shang
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引用次数: 0
Abstract
The purpose of this study was to explore the relationship between brain excitability indexed using different transcranial magnetic stimulation (TMS) measures and post-stroke fatigue (PSF) in individuals with mild to moderate motor impairment. We used single- and paired-pulse TMS to obtain various TMS outcomes from 24 participants with chronic stroke: resting motor threshold (RMT), motor evoked potential amplitude (MEP), Input-Output Curve (IOC) slope, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF). IO curve slope (ρ = -0.61, p = 0.02) and SICI (ρ = -0.51, p = .03) measured from the ipsilesional hemisphere correlated with PSF. Other TMS measures were not significantly correlated with PSF measures. Findings suggest that higher levels of fatigue were associated with lower brain excitability. Together with previous studies, our findings suggest that level of motor impairment and the tool used to assess fatigue might influence the relationship between brain excitability and PSF.
期刊介绍：
This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.
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