Emergence and clonal transmission of Elizabethkingia meningoseptica in adult and paediatric intensive care units: An integrated clinical, microbiological, and genomic analysis

IF 1.5 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI:10.1016/j.ijmmb.2025.101032

Debasish Biswal , Sharmila Sengupta , Ripenmeet Salhotra , Pankhuri Kumari , Maninder Dhaliwal , Sadia Khan , Aayush Chawla , Veena Raghunathan , Sandeep Mangla

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引用次数: 0

Abstract

Elizabethkingia meningoseptica is an emerging nosocomial pathogen with complex antimicrobial resistance. We conducted a retrospective study in intensive care units (August 2022–December 2024) involving thirteen patients (ten adults, three paediatric). Universal resistance to piperacillin/tazobactam, aminoglycosides but susceptibility to minocycline was observed. Environmental sampling revealed contamination in water outlets and sink holes. Whole genome sequencing demonstrated clonal relationships between clinical and environmental isolates, confirming nosocomial transmission. Neurological complications were significantly associated with mortality. Following targeted interventions including enhanced disinfection and thermal water flushing, no new cases occurred during three-month follow-up. This study highlights environmental surveillance and integrated infection control importance.

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“成人和儿科重症监护病房中伊丽莎白脑膜炎败血症的出现和克隆传播：综合临床、微生物学和基因组分析”。

伊莉莎白菌脑膜炎败血症是一种具有复杂抗菌素耐药性的新出现的医院病原体。我们在重症监护室进行了一项回顾性研究（2022年8月至2024年12月），涉及13名患者（10名成人，3名儿科）。普遍对哌拉西林/他唑巴坦、氨基糖苷类耐药，但对米诺环素敏感。环境抽样显示，出水口和污水坑受到污染。全基因组测序显示临床和环境分离株之间存在克隆关系，证实了医院传播。神经系统并发症与死亡率显著相关。经过有针对性的干预措施，包括加强消毒和热水冲洗，在三个月的随访期间没有发生新的病例。本研究强调了环境监测和综合感染控制的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.