Adipose-Based Therapeutics and Transplantation of Hypodermis.

IF 5.7 3区医学 Q1 DERMATOLOGY

Advances in wound care Pub Date : 2026-07-01 Epub Date: 2025-11-27 DOI:10.1177/21621918251400625

Shawn Jeffrey Loder, J Peter Rubin

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引用次数: 0

Abstract

Significance: Wound healing is a complex process, and while the epidermis and dermis receive significant attention, the role of the hypodermis is important. The adipose-rich hypodermis or subcutaneous layer supports overall skin function, and loss or injury can impair wound healing, result in adhesions and/or contracture, and restrict soft-tissue mobility. Traditional wound management methods are often insufficient for hypodermal injuries, necessitating innovative approaches.

Recent advances: Hypodermal adipose-based solutions, including fat grafting and stem cell therapies, show promise for reconstruction. Fat grafting enhances soft-tissue bulk and contour, enhances mechanical properties, and promotes angiogenesis, offering versatility in addressing a range of wound scenarios, including challenging cases. Adipose-derived stem cells exhibit regenerative potential, modulate inflammation, and facilitate tissue repair, making them valuable for scar revision, skin rejuvenation, and managing chronic wounds. Acellular adipose derivatives, such as exosomes and liquid extracts, contain bioactive molecules that support tissue regeneration and collagen production. Adipose-derived acellular extracellular matrix holds promise in wound healing by enhancing cell behavior and angiogenesis.

Critical issues: In this review, we will discuss adipose-centered options for improvement of wound healing and for restoration of the hypodermis together as a cluster of efficient and cost-effective wound management in cases of complex soft-tissue injuries.

Future directions: These innovative therapies, while requiring further research, hold significant potential to simplify procedures, reduce costs, and improve the quality of life for patients facing challenging wounds.

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脂肪为基础的治疗和皮下移植。

意义：伤口愈合是一个复杂的过程，虽然表皮和真皮受到重视，但真皮的作用也很重要。富含脂肪的皮下或皮下层支持皮肤的整体功能，丢失或损伤可损害伤口愈合，导致粘连和/或挛缩，并限制软组织的活动。传统的伤口管理方法对皮下损伤往往是不够的，需要创新的方法。最近进展：皮下脂肪为基础的解决方案，包括脂肪移植和干细胞治疗，显示出重建的希望。脂肪移植可以增强软组织的体积和轮廓，增强机械性能，促进血管生成，为解决一系列伤口情况提供了多功能性，包括具有挑战性的病例。脂肪来源的干细胞表现出再生潜力，调节炎症，促进组织修复，使它们在疤痕修复，皮肤年轻化和治疗慢性伤口方面具有价值。脱细胞脂肪衍生物，如外泌体和液体提取物，含有支持组织再生和胶原蛋白生成的生物活性分子。脂肪衍生的脱细胞细胞外基质通过增强细胞行为和血管生成在伤口愈合中具有前景。关键问题：在这篇综述中，我们将讨论以脂肪为中心的选择，以改善伤口愈合和皮下组织的修复，作为复杂软组织损伤病例中有效和经济的伤口管理方法。未来方向：这些创新疗法虽然需要进一步研究，但在简化程序、降低成本和改善面临挑战性伤口的患者的生活质量方面具有巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in wound care Medicine-Emergency Medicine

CiteScore

12.10

自引率

4.10%

发文量

期刊介绍： Advances in Wound Care rapidly shares research from bench to bedside, with wound care applications for burns, major trauma, blast injuries, surgery, and diabetic ulcers. The Journal provides a critical, peer-reviewed forum for the field of tissue injury and repair, with an emphasis on acute and chronic wounds. Advances in Wound Care explores novel research approaches and practices to deliver the latest scientific discoveries and developments. Advances in Wound Care coverage includes: Skin bioengineering, Skin and tissue regeneration, Acute, chronic, and complex wounds, Dressings, Anti-scar strategies, Inflammation, Burns and healing, Biofilm, Oxygen and angiogenesis, Critical limb ischemia, Military wound care, New devices and technologies.