Anu Shibi Anilkumar, Sheena Mariam Thomas, Ramakrishnan Veerabathiran
{"title":"Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 (<i>CYP2C19</i>) and Estrogen Receptor-1 (<i>ESR1</i>) Genetic Variants.","authors":"Anu Shibi Anilkumar, Sheena Mariam Thomas, Ramakrishnan Veerabathiran","doi":"10.1080/07357907.2025.2596854","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Breast Cancer (BC) is a leading cancer among women, influenced by genetic polymorphisms. This meta-analysis examines <i>CYP2C19</i> (rs4244285) and <i>ESR1</i> (rs2234693) polymorphisms and BC susceptibility.</p><p><strong>Methodology: </strong>A PRISMA-guided search analyzed genotypic and allelic frequencies across six CYP2C19 and nine ESR1 studies, with quality assessed by the Newcastle-Ottawa Scale and Hardy-Weinberg Equilibrium, spanning diverse ethnic groups.</p><p><strong>Results: </strong>Most models found no significant associations for CYP2C19 or ESR1. The GG genotype of <i>CYP2C19</i> (rs4244285) showed a potential protective effect against BC.</p><p><strong>Conclusion: </strong>Genetic variability impacts BC risk. <i>CYP2C19</i> (rs4244285) may offer protective effects. Further research is needed for personalized treatments.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"207-223"},"PeriodicalIF":2.2000,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07357907.2025.2596854","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Breast Cancer (BC) is a leading cancer among women, influenced by genetic polymorphisms. This meta-analysis examines CYP2C19 (rs4244285) and ESR1 (rs2234693) polymorphisms and BC susceptibility.
Methodology: A PRISMA-guided search analyzed genotypic and allelic frequencies across six CYP2C19 and nine ESR1 studies, with quality assessed by the Newcastle-Ottawa Scale and Hardy-Weinberg Equilibrium, spanning diverse ethnic groups.
Results: Most models found no significant associations for CYP2C19 or ESR1. The GG genotype of CYP2C19 (rs4244285) showed a potential protective effect against BC.
Conclusion: Genetic variability impacts BC risk. CYP2C19 (rs4244285) may offer protective effects. Further research is needed for personalized treatments.
期刊介绍：
Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.
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