Systemic immune inflammation index, systemic inflammatory response index and pan-immune inflammation value in the prediction of idiopathic late-onset fetal growth restriction

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI:10.1016/j.cyto.2025.157081

Murat Levent Dereli , Sadun Sucu , Dilara Sarıkaya Kurt , Ahmet Kurt , Fahri Burçin Fıratlıgil , Tuğba Ağbal , Ali Turhan Çağlar

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引用次数: 0

Abstract

Background

Fetal growth restriction (FGR) is a major pregnancy complication associated with stillbirth, perinatal morbidity, mortality and long-term consequences for the offspring. Therefore, its prediction, early detection and appropriate follow-up are essential components of prenatal care. In most cases, also referred to as late-onset idiopathic FGR (IL-FGR), symptoms appear after 34 weeks and the underlying pathology is unclear. Our aim was to investigate the relationship between altered inflammation and pathogenesis using inflammatory indices calculated from the complete blood count.

Methods

We conducted a retrospective case-control study in a large tertiary hospital between 2022 and 2023. Data from all participants at the time of screening for fetal aneuploidy and structural anomalies at 11–14 weeks were retrospectively reviewed and compared.

Results

A total of 106 eligible participants with IL-FGR and 106 women who experienced a healthy prenatal and perinatal period were included. Neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), pan-immune inflammation value (PIV) and SIRI/body-mass index (BMI) were significantly higher in the IL-FGR group (p < 0.001 for all). SIRI/BMI with a cut-off value of >76.3 × 10³ × kg/μL × m² (64 % sensitivity, 80 % specificity) showed the best discriminatory performance for IL-FGR prediction. Correlation analysis of gestational age-adjusted parameters with these indices showed a negative correlation with birthweight, suggesting that higher values of the inflammatory indices at the 11–14-week aneuploidy screening are associated with a greater likelihood of severe IL-FGR.

Conclusions

Our results suggest an association between high SII, SIRI, PIV and SIRI/BMI and an increased risk of future IL-FGR. SIRI/BMI may be an important component of regression models that could be used in the future as a screening tool for predicting FGR. However, our results require further validation by future studies to confirm the specific clinical implications of these indices.

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全身性免疫炎症指数、全身性炎症反应指数和泛免疫炎症在预测特发性迟发性胎儿生长受限中的价值

胎儿生长受限（FGR）是一种主要的妊娠并发症，与死产、围产期发病率、死亡率和后代的长期后果有关。因此，其预测，早期发现和适当的随访是产前护理的重要组成部分。在大多数病例中，也被称为迟发性特发性FGR (IL-FGR)，症状在34周后出现，潜在病理尚不清楚。我们的目的是通过全血细胞计数计算炎症指数来研究炎症改变与发病机制之间的关系。方法于2022 - 2023年在某大型三级医院进行回顾性病例对照研究。所有参与者在11-14周进行胎儿非整倍体和结构异常筛查时的数据进行回顾性回顾和比较。结果共纳入106名IL-FGR患者和106名产前和围产期健康的妇女。中性粒细胞与淋巴细胞比率（NLR）、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）、泛免疫炎症值（PIV）和SIRI/体重指数（BMI）在IL-FGR组均显著升高（p < 0.001）。SIRI/BMI的临界值为76.3 × 103 × kg/μL × m2（敏感性64%，特异性80%），对IL-FGR的预测具有最佳的鉴别效果。孕龄调整参数与这些指标的相关性分析显示，这些指标与出生体重呈负相关，表明在11 - 14周非整倍体筛查时，炎症指标越高，发生严重IL-FGR的可能性越大。结论高SII、SIRI、PIV和SIRI/BMI与未来IL-FGR风险增加有关。SIRI/BMI可能是回归模型的一个重要组成部分，可以作为未来预测FGR的筛选工具。然而，我们的结果需要通过未来的研究进一步验证，以确认这些指标的具体临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.