Inhibition of periodontitis progression by a non-steroidal inhibitor of steroid sulfatase in healing-impaired conditions: a preclinical rodent model pilot experiment.

IF 3.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Periodontal and Implant Science Pub Date : 2026-06-01 Epub Date: 2025-10-01 DOI:10.5051/jpis.2404220211

Young Woo Song, Ji Min Choi, Yoon-Hee Kwon, Jin-Young Park, Jae-Kook Cha, Sung-Jin Kim, Jeong Taeg Seo, Seok Jun Moon, Dong Min Shin, Ui-Won Jung

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Abstract

Purpose: This study investigated the potential effect of increasing systemic cholesterol sulfate (CS) levels by applying a non-steroidal inhibitor of steroid sulfatase (STS inhibitor) on the progression of periodontitis in osteoporosis-induced rats.

Methods: A total of 16 ovariectomized female Sprague-Dawley rats were used, and periodontitis was induced by placing non-resorbable suture material around the maxillary second molars bilaterally for 5 weeks. During this period, the animals received either STS inhibitor-mixed feed (high-CS group, n=8) or conventional feed (control group, n=8). At 5 weeks after periodontitis induction, histologic outcomes were statistically compared between the 2 groups (P<0.05).

Results: The high-CS group showed significantly shorter distances between the cemento-enamel junction (CEJ) and the apical location of the junctional epithelium at proximal sites (0.12 mm shorter on average) and between the CEJ and the alveolar bone crest at proximal sites (0.19 mm shorter on average) compared with the control group. The mean areal percentage of alveolar bone within the furcation area was also significantly higher in the high-CS group (11.82% higher on average) than in the control group.

Conclusions: Increasing systemic CS levels may suppress periodontal tissue destruction caused by periodontitis in ovariectomized rats.

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在愈合受损的条件下，类固醇磺化酶的非甾体抑制剂对牙周炎进展的抑制：一项临床前啮齿动物模型先导实验。

目的：探讨应用非甾体类类固醇硫酸酯酶抑制剂（STS抑制剂）提高全身硫酸胆固醇（CS）水平对骨质疏松大鼠牙周炎进展的影响。方法：选取16只切除卵巢的雌性Sprague-Dawley大鼠，在双侧上颌第二磨牙周围放置不可吸收缝线材料诱导牙周炎5周。在此期间，动物分别饲喂STS抑制剂混合饲料（高cs组，n=8）和常规饲料（对照组，n=8）。诱导牙周炎后5周，两组患者组织学结果比较，差异有统计学意义（P0.05）。结果：高cs组牙髓-牙釉质交界处（CEJ）与近端接合上皮顶端位置之间的距离（平均缩短0.12 mm）和近端牙槽骨嵴之间的距离（平均缩短0.19 mm）均明显缩短。高cs组分岔区牙槽骨的平均面积百分比也显著高于对照组（平均高11.82%）。结论：增加全身CS水平可抑制去卵巢大鼠牙周炎引起的牙周组织破坏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.