{"title":"Recent progress in regulation of aging by non-coding RNAs in <i>Caenorhabditis elegans</i>.","authors":"Seungjae Hwang, Woojin Hong, Seung-Jae V Lee","doi":"10.1080/19768354.2025.2593037","DOIUrl":null,"url":null,"abstract":"<p><p>Non-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Recent advances in RNA biology have uncovered roles of ncRNAs in physiological processes, including aging. Here, we review how various classes of ncRNAs regulate aging and longevity, by focusing on recent research using the nematode <i>Caenorhabditis elegans</i>, an excellent model for aging research. We also discuss the potential of ncRNAs as diagnostic biomarkers and therapeutic targets for aging and age-related diseases. Because many aging-regulating genes and pathways in <i>C. elegans</i> are evolutionarily conserved, our review will provide important information regarding the functions of ncRNAs in aging and longevity in other species, including mammals.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"665-675"},"PeriodicalIF":3.2000,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667324/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Cells and Systems","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/19768354.2025.2593037","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Non-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Recent advances in RNA biology have uncovered roles of ncRNAs in physiological processes, including aging. Here, we review how various classes of ncRNAs regulate aging and longevity, by focusing on recent research using the nematode Caenorhabditis elegans, an excellent model for aging research. We also discuss the potential of ncRNAs as diagnostic biomarkers and therapeutic targets for aging and age-related diseases. Because many aging-regulating genes and pathways in C. elegans are evolutionarily conserved, our review will provide important information regarding the functions of ncRNAs in aging and longevity in other species, including mammals.
期刊介绍：
Animal Cells and Systems is the official journal of the Korean Society for Integrative Biology. This international, peer-reviewed journal publishes original papers that cover diverse aspects of biological sciences including Bioinformatics and Systems Biology, Developmental Biology, Evolution and Systematic Biology, Population Biology, & Animal Behaviour, Molecular and Cellular Biology, Neurobiology and Immunology, and Translational Medicine.
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