{"title":"An accessible approach to density estimation neural networks with data preprocessing.","authors":"Bosi Hou, Jonathan E Rubin","doi":"10.3934/mbe.2025116","DOIUrl":null,"url":null,"abstract":"<p><p>Density estimation neural networks (DENNs) represent a form of artificial neural network designed to provide an efficient approach to the Bayesian estimation of a probability density on a model parameter space, conditioned on an empirical observation of the underlying system. Despite their efficiency and potential, DENNs remain underutilized for parameter estimation in mathematical modeling. In this work, we aim to boost the accessibility of the DENN approach by providing a user-friendly introduction and code that makes it easy for users to harness existing, cutting-edge DENN software. Furthermore, we insert an easily-implemented preliminary data simulation step that reduces the computational demands of the approach and empirically demonstrates that it maintains the accuracy of parameter estimation for a stochastic oscillator model.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"22 12","pages":"3130-3153"},"PeriodicalIF":2.6000,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mathematical Biosciences and Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3934/mbe.2025116","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Mathematics","Score":null,"Total":0}
引用次数: 0
Abstract
Density estimation neural networks (DENNs) represent a form of artificial neural network designed to provide an efficient approach to the Bayesian estimation of a probability density on a model parameter space, conditioned on an empirical observation of the underlying system. Despite their efficiency and potential, DENNs remain underutilized for parameter estimation in mathematical modeling. In this work, we aim to boost the accessibility of the DENN approach by providing a user-friendly introduction and code that makes it easy for users to harness existing, cutting-edge DENN software. Furthermore, we insert an easily-implemented preliminary data simulation step that reduces the computational demands of the approach and empirically demonstrates that it maintains the accuracy of parameter estimation for a stochastic oscillator model.
期刊介绍:
Mathematical Biosciences and Engineering (MBE) is an interdisciplinary Open Access journal promoting cutting-edge research, technology transfer and knowledge translation about complex data and information processing.
MBE publishes Research articles (long and original research); Communications (short and novel research); Expository papers; Technology Transfer and Knowledge Translation reports (description of new technologies and products); Announcements and Industrial Progress and News (announcements and even advertisement, including major conferences).