Effect of isofetamid on SDHI-resistant isolates of Botrytis cinerea.

IF 1.5 4区农林科学 Q2 ENTOMOLOGY

Journal of Pesticide Science Pub Date : 2025-11-20 DOI:10.1584/jpestics.D25-053

Yuzuka Abe, Yoshitake Desaki, Nanami Kuwahara, Yohei Fukumori, Shintaro Tsukuda, Kosuke Tsunematsu, Sayaka Komori, Munekazu Ogawa, Satoshi Araki, Shigeru Mitani, Kazumi Suzuki

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Abstract

Tests of sensitivity to isofetamid conducted with Botrytis cinerea isolated from Hokkaido (2011-2016) and other districts in Japan (2017-2018) revealed the absence of isolates with reduced sensitivity. Isolates of B. cinerea with mutation H272Y/R in sdhB, collected in Germany and Japan, resulted in high and moderate resistance to boscalid and many other succinate dehydrogenase inhibitors (SDHIs), respectively. However, these isolates were as sensitive as wild-type isolate to isofetamid. In contrast, isolate BC-50 [P225F] and BC-49 [H272L] caused moderate to high resistance to isofetamid. Considerable differences in mycelial growth, conidiation, conidial germination, and pathogenicity were not observed between these resistant isolates and sensitive isolates. A competitive assay between resistant isolate BC-50 [P225F] and BC-49 [H272L] and B05.10 [wild type], however, revealed the disappearance of resistant isolates after several generations of mixed incubation in in vitro and in vivo conditions.

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异fetamid对葡萄孢sdhi耐药菌株的影响。

从北海道（2011-2016年）和日本其他地区（2017-2018年）分离的灰葡萄孢菌对异非达木的敏感性试验显示，未发现敏感性降低的分离株。在德国和日本采集的琥珀酸脱氢酶H272Y/R突变的灰绿杆菌分离株，分别对boscalid和许多其他琥珀酸脱氢酶抑制剂（SDHIs）产生高抗性和中等抗性。然而，这些分离株对异fetamid的敏感性与野生型一样。相比之下，BC-50 [P225F]和BC-49 [H272L]对异苯达蜜酯产生中至高抗性。耐药菌株和敏感菌株在菌丝生长、分生孢子、分生孢子萌发和致病性方面没有明显差异。然而，耐药菌株BC-50 [P225F]、BC-49 [H272L]和B05.10[野生型]之间的竞争分析显示，在体外和体内条件下混合培养几代后，耐药菌株消失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pesticide Science 农林科学-昆虫学

CiteScore

4.30

自引率

4.20%

发文量

审稿时长

18-36 weeks

期刊介绍： The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.