Advances to fertility preservation in patients with gynecological cancers.

IF 2.9 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI:10.1080/17446651.2025.2596680

Loris Marin, Nazli Aylin Vural, Kutluk H Oktay

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引用次数: 0

Abstract

Introduction: Fertility preservation has become increasingly important in the multidisciplinary care of women with gynecologic cancers, especially as delayed childbearing has contributed to a rise in cancer diagnoses during reproductive ages. In this context, advancements in fertility preservation have greatly enhanced the variety of strategies offered to women facing gynecologic cancers, offering both established and emerging options to women diagnosed with cervical, endometrial, and ovarian malignancies.

Areas covered: This review provides a comprehensive overview of current fertility-preserving approaches in gynecologic oncology, highlighting latest developments in surgical, medical, and assisted reproductive techniques. A literature search was conducted in PubMed, Scopus, EMBASE, and Web-of-Science (2010-2025). We examine the indications, oncologic safety, and reproductive outcomes of fertility-sparing procedures, including radical trachelectomy, hormonal therapy for early-stage endometrial cancer, and conservative management of borderline ovarian tumors. Additionally, we discuss the role and timing of oocyte/embryo and ovarian tissue cryopreservation, particularly in urgent gynecologic oncological case scenarios. Critical challenges such as optimal patient selection, individualized risk assessment, and coordination between gynecologic oncology and fertility specialists are addressed.

Expert opinion: Fertility preservation in gynecologic oncology has evolved considerably, yet several unmet needs remain, and future research with a focus on improving oncologic and reproductive outcomes is needed.

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妇科癌症患者保留生育能力的研究进展。

在妇科癌症患者的多学科治疗中，保留生育能力变得越来越重要，特别是由于生育延迟导致育龄期癌症诊断的增加。在这种情况下，生育能力保存方面的进步极大地增加了为面临妇科癌症的妇女提供的各种策略，为诊断为宫颈、子宫内膜和卵巢恶性肿瘤的妇女提供了既有的和新出现的选择。涵盖领域：这篇综述提供了目前妇科肿瘤保留生育能力方法的全面概述，重点介绍了外科、医学和辅助生殖技术的最新发展。在PubMed、Scopus、EMBASE和Web-of-Science（2010-2025）中进行文献检索。我们研究了保留生育能力手术的适应症、肿瘤安全性和生殖结果，包括根治性气管切除术、早期子宫内膜癌的激素治疗和交界性卵巢肿瘤的保守治疗。此外，我们还讨论了卵母细胞/胚胎和卵巢组织冷冻保存的作用和时机，特别是在紧急妇科肿瘤病例情况下。关键的挑战，如最佳的患者选择，个性化的风险评估，妇科肿瘤和生育专家之间的协调解决。专家意见：妇科肿瘤的生育能力保存已经有了很大的发展，但仍有一些未满足的需求，未来的研究需要关注改善肿瘤和生殖结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.