N A Kutukova, A S Trulioff, A V Polevshchikov, O V Shamova
{"title":"Dual Effects of Acetylcholine on Mast Cell-Nerve Interactions.","authors":"N A Kutukova, A S Trulioff, A V Polevshchikov, O V Shamova","doi":"10.1134/S001249662560054X","DOIUrl":null,"url":null,"abstract":"<p><p>Mast cell (MC)-nerve units are one of the main elements of cooperation between the nervous and immune systems, providing a structural and functional connection between MCs and autonomic nerve fibers. Although immunoregulatory activity of acetylcholine (ACh) is well established, the exact point of its influence on MCs remains unclear. This study compared the effects of muscarinic (mAChR) versus nicotinic (nAChR) ACh receptor binding on secretory activity of HMC-1 cells. It was found that ACh activates intact MCs mainly through the M3 mAChR, but suppresses degranulation in stimulated MCs via the α7 nAChR. The findings indicate that changes in the receptor pattern within MC-nerve units underlie the dual effects of ACh and enable MCs to switch functions in inflammation from proinflammatory activity in the acute phase to anti-inflammatory activity during reparation.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"350-353"},"PeriodicalIF":0.0000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/S001249662560054X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
Mast cell (MC)-nerve units are one of the main elements of cooperation between the nervous and immune systems, providing a structural and functional connection between MCs and autonomic nerve fibers. Although immunoregulatory activity of acetylcholine (ACh) is well established, the exact point of its influence on MCs remains unclear. This study compared the effects of muscarinic (mAChR) versus nicotinic (nAChR) ACh receptor binding on secretory activity of HMC-1 cells. It was found that ACh activates intact MCs mainly through the M3 mAChR, but suppresses degranulation in stimulated MCs via the α7 nAChR. The findings indicate that changes in the receptor pattern within MC-nerve units underlie the dual effects of ACh and enable MCs to switch functions in inflammation from proinflammatory activity in the acute phase to anti-inflammatory activity during reparation.
期刊介绍：
Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
