The Role of Ubiquitination Regulation in Nasopharyngeal Carcinoma.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI:10.1080/07357907.2025.2597501

Zhenyu Yan, Xiang Cao, Chengxian Ma, Yizhi Ge, Dan Zong, Xia He

引用次数: 0

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignant head and neck tumors. Despite being sensitive to radiation, the prognosis of some NPC patients remains unoptimistic due to the resistance to therapeutic approaches. Ubiquitination is a crucial post-translational modification of proteins, and is key to maintaining protein homeostasis in vivo. Studies have shown that ubiquitination modification can regulate cell proliferation, apoptosis, and other processes, thereby affecting the development of NPC. In this review, we summarize the research on ubiquitination regulation in NPC, aiming to explore new therapeutic targets and provide feasible solutions to improve the prognosis of NPC patients.

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泛素化调控在鼻咽癌中的作用。

鼻咽癌是头颈部最常见的恶性肿瘤之一。尽管对放射敏感，但由于对治疗方法的抵抗，一些鼻咽癌患者的预后仍然不容乐观。泛素化是一种重要的蛋白质翻译后修饰，是维持体内蛋白质稳态的关键。研究表明，泛素化修饰可以调节细胞增殖、凋亡等过程，从而影响鼻咽癌的发展。本文就泛素化调控在鼻咽癌中的研究进展进行综述，旨在探索新的治疗靶点，为改善鼻咽癌患者的预后提供可行的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.