Evaluation of the Antitumor Effect of High-Energy Protons, Helium Ions, and Carbon during Irradiation of Ehrlich Adenocarcinoma Ascites Cells Ex Vivo

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2025-12-02 DOI:10.1134/S1607672925601209

V. E. Balakin, N. S. Strelnikova, O. M. Rozanova, E. N. Smirnova, T. A. Belyakova, A. V. Smirnov

引用次数: 0

Abstract

The regularities of tumor induction and growth in mice were studied during a single ex vivo irradiation of Ehrlich adenocarcinoma ascites cells with a beam of protons, helium ions (⁴Не), and carbon ions (¹²С) at doses of 10, 20, and 30 Gy. It was shown that, when tumor cells were exposed to all types of radiation, a dose-dependent increase in the antitumor effect was observed in the latent period of tumor appearance, the frequency of their induction, and tumor growth inhibition. According to all indices, ¹²C had the greatest antitumor effect, ⁴He occupied an intermediate position, and protons caused the least effect.

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体外评价高能质子、氦离子和碳辐照埃利希腺癌腹水细胞的抗肿瘤作用。

研究了质子束、氦离子束（4Не）和碳离子束（12С）在10、20和30 Gy剂量下对埃利希腺癌腹水细胞单次体外照射诱导小鼠肿瘤和生长的规律。结果表明，当肿瘤细胞暴露于各种类型的辐射时，在肿瘤出现的潜伏期、诱导频率和肿瘤生长抑制方面，抗肿瘤作用均呈剂量依赖性增加。综合各项指标，12C的抗肿瘤作用最大，4He居中，质子作用最小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.