Research on quantitative assessment of renal tubular function based on renal dynamic imaging

Revista espanola de medicina nuclear e imagen molecular Pub Date : 2026-05-01 Epub Date: 2025-11-28 DOI:10.1016/j.remnie.2025.500268

W. Liu, G. Yao, Y. Gao, C. Wang

{"title":"Research on quantitative assessment of renal tubular function based on renal dynamic imaging","authors":"W. Liu, G. Yao, Y. Gao, C. Wang","doi":"10.1016/j.remnie.2025.500268","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To establish a renal tubular uptake rate (RTUR) model based on renal dynamic imaging (RDI) for detecting early tubular injury and to explore its clinical application value.</div></div><div><h3>Materials and methods</h3><div>RDI data collected from August 2020 to June 2025 were analyzed. A total of 292 eligible cases (441 kidneys) were included. Participants were categorized into: - Control group: 56 cases (112 kidneys) - Renal insufficiency group: 93 cases (186 kidneys) - Fully compensated group: 62 cases (62 kidneys) - Partially compensated group: 35 cases (35 kidneys) - Decompensated group: 46 cases (46 kidneys).</div></div><div><h3>RTUR calculation formula</h3><div>RTUR = (Ascent slope of renal scintigraphy/Total injected radioactive drug activity) × 10<sup>5</sup> × 100%.</div></div><div><h3>Analysis content</h3><div>Distribution of RTUR values across five groups; correlation between GFR and RTUR in 441 kidneys. Differences in RTUR between the control group and other four groups; diagnostic efficacy and clinical value of RTUR.</div></div><div><h3>Results</h3><div>Compared with the control group, significant differences in RTUR were observed in the renal insufficiency group, fully compensated group, and decompensated group (<em>P</em> < .01). GFR in 441 kidneys showed a strong positive correlation with RTUR (r = 0.739, <em>P</em> < .001). ROC analysis indicated that RTUR ≤ 5.225% identified renal insufficiency (sensitivity 77.7%, specificity 70.4%), while RTUR ≥ 9.135% diagnosed complete renal compensation with 82.3% sensitivity.</div></div><div><h3>Conclusion</h3><div>The RTUR model enables stable quantitative assessment of renal tubular reabsorption rate, facilitating diagnosis of renal insufficiency and complete renal compensation. It holds promise as a novel quantitative indicator for evaluating tubular function. Renal GFR exhibits a strong correlation with RTUR.</div></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":"45 3","pages":"Article 500268"},"PeriodicalIF":0.0000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de medicina nuclear e imagen molecular","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253808925001740","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/28 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To establish a renal tubular uptake rate (RTUR) model based on renal dynamic imaging (RDI) for detecting early tubular injury and to explore its clinical application value.

Materials and methods

RDI data collected from August 2020 to June 2025 were analyzed. A total of 292 eligible cases (441 kidneys) were included. Participants were categorized into: - Control group: 56 cases (112 kidneys) - Renal insufficiency group: 93 cases (186 kidneys) - Fully compensated group: 62 cases (62 kidneys) - Partially compensated group: 35 cases (35 kidneys) - Decompensated group: 46 cases (46 kidneys).

RTUR calculation formula

RTUR = (Ascent slope of renal scintigraphy/Total injected radioactive drug activity) × 10⁵ × 100%.

Analysis content

Distribution of RTUR values across five groups; correlation between GFR and RTUR in 441 kidneys. Differences in RTUR between the control group and other four groups; diagnostic efficacy and clinical value of RTUR.

Results

Compared with the control group, significant differences in RTUR were observed in the renal insufficiency group, fully compensated group, and decompensated group (P < .01). GFR in 441 kidneys showed a strong positive correlation with RTUR (r = 0.739, P < .001). ROC analysis indicated that RTUR ≤ 5.225% identified renal insufficiency (sensitivity 77.7%, specificity 70.4%), while RTUR ≥ 9.135% diagnosed complete renal compensation with 82.3% sensitivity.

Conclusion

The RTUR model enables stable quantitative assessment of renal tubular reabsorption rate, facilitating diagnosis of renal insufficiency and complete renal compensation. It holds promise as a novel quantitative indicator for evaluating tubular function. Renal GFR exhibits a strong correlation with RTUR.

查看原文本刊更多论文

基于肾动态成像的肾小管功能定量评价研究。

目的：建立基于肾动态成像（RDI）的肾小管摄取率（RTUR）模型，用于早期检测肾小管损伤，并探讨其临床应用价值。材料与方法：对2020年8月至2025年6月收集的RDI数据进行分析。总共纳入292例符合条件的病例（441个肾脏）。参与者分为：-对照组：56例（112个肾脏）-肾功能不全组：93例（186个肾脏）-完全代偿组：62例（62个肾脏）-部分代偿组：35例（35个肾脏）-失代偿组：46例（46个肾脏）RTUR计算公式：RTUR =（肾扫描上升斜率/总注射放射性药物活性）×10 ×100%。分析内容：五组RTUR值分布；441个肾脏GFR与RTUR的相关性。对照组与其他四组RTUR的差异；RTUR的诊断效果及临床价值。结果：与对照组相比，肾功能不全组、完全代偿组和失代偿组的RTUR均有显著差异(P)。结论：RTUR模型能够稳定地定量评估肾小管重吸收率，有助于诊断肾功能不全和肾完全代偿。它有望成为评价肾小管功能的一种新的定量指标。肾GFR与RTUR有很强的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista espanola de medicina nuclear e imagen molecular

自引率

0.00%

发文量