Total-Body PET/CT Metabolic Response in Esophageal Squamous Cell Carcinoma

IF 6.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2026-01-01 Epub Date: 2025-11-29 DOI:10.1053/j.semnuclmed.2025.11.010

Runjun Yang , Xinyi Lu , Wenxin Tang , Lorenzo Nardo , Yunze Xie , Akram Al-Ibraheem , Lichao Zhang , Wenjin Zhao , Axel Rominger , Lijie Tan , Han Tang , Ida Nur Syafinaz Binti Muhammad Fuad , Subapriya Suppiah , Eric Cruz , Yu Lin , Haojun Yu , Hongcheng Shi

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引用次数: 0

Abstract

Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to neoadjuvant therapy, necessitating early and accurate assessment. [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) PET/CT enables quantitative assessment of tumor glucose metabolism, correlating with pathological remission and long-term outcomes, while [¹⁸F] or [⁶⁸Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT evaluates stromal metabolism, providing complementary information. Total-body PET/CT (uEXPLORER, United Imaging Healthcare Co.Ltd., Shanghai, China) with 194-cm long-axial field-of-view (LAFOV) offers long axial coverage, up to 68-fold higher sensitivity than conventional systems. It enables low-dose, rapid imaging, dynamic whole-body parametric imaging, and improves detection of small, low-uptake lesions as well as metastatic lesions in the distal upper or lower extremities in a single bed position. Delayed and dual-time imaging protocols, alone and/or combined with deep learning–based synthetic CT, further improve lesion detectability while minimizing radiation exposure. This narrative review summarizes evidence from conventional PET/CT studies, highlights the technical and clinical advantages of total-body PET/CT, and discusses its feasibility, quantitative capabilities, and potential to guide response-adapted management in ESCC based on our institutional experience.

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食管鳞状细胞癌的全身PET/CT代谢反应

食管鳞状细胞癌（ESCC）表现出对新辅助治疗的异质性反应，需要早期和准确的评估。[18F]氟脱氧葡萄糖（[18F]FDG） PET/CT能够定量评估肿瘤糖代谢，与病理缓解和长期预后相关，而[18F]或[68Ga] ga标记的成纤维细胞活化蛋白抑制剂（FAPI） PET/CT评估间质代谢，提供补充信息。全身PET/CT （uEXPLORER, United Imaging Healthcare ltd .）（上海，中国）拥有194厘米长轴向视场（LAFOV），提供长轴向覆盖，灵敏度比传统系统高68倍。它可以实现低剂量，快速成像，动态全身参数成像，并提高对单床位置上肢或下肢远端小，低摄取病变以及转移性病变的检测。延迟和双时间成像方案，单独和/或结合基于深度学习的合成CT，进一步提高病变的可检测性，同时最大限度地减少辐射暴露。本文总结了传统PET/CT研究的证据，强调了全身PET/CT的技术和临床优势，并根据我们的机构经验讨论了其可行性、定量能力和指导ESCC响应适应管理的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.