Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis

IF 20.3 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-11-29 DOI:10.1016/j.semcancer.2025.11.024

Ya-Ting Chuang , Ching-Yu Yen , Yi-Hong Tsai , Fang-Rong Chang , Ammad Ahmad Farooqi , Hsueh-Wei Chang

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引用次数: 0

Abstract

Signaling lipids have been shown to play multifaceted roles ranging from cell proliferation, metabolism, invasion, migration, and apoptosis. Mechanistically, these enzymes and their downstream targets constitute complicated and intertwined lipid signaling networks with multiple nodes of interaction and cross-regulations. Dysregulated lipid metabolism is one of the hallmarks of cancer. Targeting such lipid metabolism is a potential anticancer strategy. Several natural products and miRNAs have been reported to modulate cancer cell fatty acid (FA) metabolisms; however, the integrated connections between these natural products, miRNAs, and targets have yet to be evaluated in detail. This review uses the bioinformatic STRING tool to explore target-target interactions between Google Scholar-retrieval targets of dysregulated FA metabolism in cancer cells. miRNAs and natural products that dysregulate FA metabolism were also retrieved and connected to the STRING–target network with Google Scholar and the bioinformatic databases (miRTarBase and miRDB), which retrieves targets for miRNAs. Moreover, the knowledge gaps between miRNA- and natural product-modulated FA metabolism are intricately connected. Consequently, this review highlights and shows interactions within the natural product–miRNA–target axis in counteracting the dysregulated FA metabolism in cancer cells.

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肿瘤中的脂质代谢受天然产物- mirna -靶标轴的综合调控。

信号脂质在细胞增殖、代谢、侵袭、迁移和凋亡等方面发挥着多方面的作用。从机制上讲，这些酶及其下游靶点构成了复杂而交织的脂质信号网络，具有多个相互作用和交叉调节的节点。脂质代谢失调是癌症的标志之一。靶向这种脂质代谢是一种潜在的抗癌策略。一些天然产物和mirna已经被报道可以调节癌细胞脂肪酸（FA）代谢；然而，这些天然产物、mirna和靶标之间的综合联系尚未得到详细的评估。本文利用生物信息学的STRING工具来探讨肿瘤细胞中FA代谢失调的谷歌学者检索靶标之间的靶标相互作用。通过谷歌Scholar和生物信息学数据库（miRTarBase和miRDB）检索并连接到STRING-target网络，检索mirna的靶标。此外，miRNA和天然产物调节的FA代谢之间的知识差距是错综复杂的。因此，本综述强调并展示了天然产物- mirna -靶标轴在对抗癌细胞中失调的FA代谢中的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.