The Association Between Dietary Protein Intake and Gallstone Disease: A Case-Control Study.

IF 1.6 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2025-11-20 eCollection Date: 2025-01-01 DOI:10.1155/grp/7362453

Amir Sadeghi, Nastaran Raissi-Dehkordi, Azita Hekmatdoost, Moloud Ghorbani, Reyhaneh Rastegar, Mohammad Reza Zali, Negar Raissi-Dehkordi, Zahra Yari

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Abstract

Background: Diet is a modifiable risk factor for gallstone formation and influence the risk of gallstone disease (GSD). The present study was designed with the aim of investigating the association between different dietary protein and the risk of GSD.

Methods: This case-control study was conducted on 189 patients diagnosed with GSD and 342 controls. Intake of total protein and its subgroups was measured based on food frequency questionnaire. Using multiple logistic regression models, crude and multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.

Results: Total protein intake can have protective effects against GSD and its beneficial effect was more in moderate consumption (OR_T2 vs.T1 = 0.2, 95% CI 0.1-0.4) than high consumption (OR_T3 vs.T1 = 0.39, 95% CI 0.23-0.66) (p for trend < 0.001). The relationship between dairy protein intake and the risk of GSD was U-shaped, so that moderate intake was associated with a reduced risk (OR_T2 vs.T1 = 0.76) and higher intake was associated with an increased risk of the disease (OR_T3 vs.T1 = 1.5) (p for trend = 0.027). Vegetable protein as a protective factor and animal protein as a risk factor showed a significant relationship with the risk of GSD.

Conclusion: Dietary protein intake, especially vegetable protein, may protect against GSD, while animal protein may be a predisposing factor. Dairy protein protects against GSD when consumed in moderation, but higher intakes may increase the risk of GSD.

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膳食蛋白质摄入与胆结石疾病之间的关系：一项病例对照研究

背景：饮食是胆结石形成的一个可改变的危险因素，并影响胆结石病（GSD）的风险。本研究旨在探讨不同膳食蛋白质与GSD风险之间的关系。方法：对189例确诊为GSD的患者和342例对照组进行病例对照研究。采用食物频率问卷法测定总蛋白摄入量及其亚组。使用多元逻辑回归模型，估计粗比值比和多变量调整比值比（ORs）和95%置信区间（ci）。结果：总蛋白摄食对GSD具有保护作用，且适量摄食（ORT2）对GSD的有益作用更大。T1 = 0.2, 95% CI 0.1-0.4)比高摄取量(ORT3 vs。T1 = 0.39, 95% CI 0.23-0.66) （p表示趋势< 0.001）。乳蛋白摄入量与GSD风险之间呈u型关系，因此适量摄入与降低风险相关（ORT2 vs. ORT2）。T1 = 0.76)，较高的摄入量与疾病风险增加相关(ORT3 vs。T1 = 1.5) （p为趋势= 0.027）。植物蛋白作为保护因子和动物蛋白作为危险因子与GSD的发生有显著关系。结论：膳食蛋白质，尤其是植物蛋白对GSD有保护作用，而动物蛋白可能是GSD的易感因素。适量食用乳制品蛋白质可以预防GSD，但摄入量过高可能会增加GSD的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.