Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study.

IF 4.5 4区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food & Nutrition Research Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI:10.29219/fnr.v69.11489

Dapeng Wang, Li Zhang, Yanfen Cui, Ruyuan Guo, Fuli Zhang, Junjie Zhang, Xiaotang Yang

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引用次数: 0

Abstract

Background: The relationship between 25-hydroxyvitamin D (25(OH)D) levels and the risk of laryngeal cancer (LC) is unclear. This study aimed to explore the causal association between 25(OH)D levels and LC risk using the two-sample Mendelian randomization (MR) analysis.

Methods: Single-nucleotide polymorphisms for 25(OH)D levels and LC were extracted from published genome-wide association studies (GWAS) or the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) Open GWAS project. Univariable MR and multivariable MR analyses were performed. Five MR methods including MR-Egger, weighted-median, inverse-variance weighted (IVW), simple mode, and weighted mode were applied.

Results: Univariable MR analysis identified the fact that genetically predicted higher levels of 25(OH)D were associated with lower odds of LC [IVW: (odds ratio (OR) = 0.9993, 95% confidence interval (CI), 0.9987-0.9999; P = 0.019)]. Multivariable MR analyses suggested that genetically predicted higher levels of 25(OH)D were correlated with lower risk of LC after adjusting for pack-years of cigarette smoking (CS) [IVW: (OR = 0.9993, 95% CI, 0.9987-0.9998; P = 0.006)] or both pack-years of CS and weekly alcoholic drinks [IVW: (OR = 0.9993, 95% CI, 0.9988-0.9998; P = 0.011)], but this was not significant after adjusting only for weekly alcoholic drinks [IVW: (OR = 0.9995, 95% CI, 0.9989-1.0001; P = 0.077)].

Conclusions: This MR analyses supported a slight protective effect of higher levels of 25(OH)D on the risk of LC.

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查看原文本刊更多论文

25-羟基维生素D水平与喉癌风险之间的因果关系：一项双样本孟德尔随机研究。

背景：25-羟基维生素D （25(OH)D）水平与喉癌（LC）风险之间的关系尚不清楚。本研究旨在通过双样本孟德尔随机化（MR）分析探讨25(OH)D水平与LC风险之间的因果关系。方法：从已发表的全基因组关联研究（GWAS）或医学研究委员会综合流行病学单位（MRC-IEU）开放GWAS项目中提取25(OH)D水平和LC的单核苷酸多态性。进行单变量MR和多变量MR分析。采用MR- egger、加权中位数、反方差加权（IVW）、简单模式和加权模式5种MR方法。结果：单变量MR分析发现，基因预测较高水平的25(OH)D与较低的LC几率相关[IVW:(优势比(OR) = 0.9993, 95%可信区间（CI）， 0.9987-0.9999；P = 0.019)]。先生多变量分析表明基因预测高25 (OH) D水平较低的相关信用证的风险调整后的久吸烟(CS) [IVW: (OR = 0.9993, 95% CI, 0.9987 - -0.9998; P = 0.006))或两个久CS和每周的酒精饮料(IVW: (OR = 0.9993, 95% CI, 0.9988 - -0.9998; P = 0.011)),但这不是重要的调整后只有每周的酒精饮料(IVW: (OR = 0.9995, 95% CI, 0.9989 - -1.0001; P = 0.077)]。结论：MR分析支持高水平的25(OH)D对LC风险有轻微的保护作用。

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来源期刊

Food & Nutrition Research FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS

CiteScore

5.20

自引率

9.10%

发文量

审稿时长

14 weeks

期刊介绍： Food & Nutrition Research is a peer-reviewed journal that presents the latest scientific research in various fields focusing on human nutrition. The journal publishes both quantitative and qualitative research papers. Through an Open Access publishing model, Food & Nutrition Research opens an important forum for researchers from academic and private arenas to exchange the latest results from research on human nutrition in a broad sense, both original papers and reviews, including: * Associations and effects of foods and nutrients on health * Dietary patterns and health * Molecular nutrition * Health claims on foods * Nutrition and cognitive functions * Nutritional effects of food composition and processing * Nutrition in developing countries * Animal and in vitro models with clear relevance for human nutrition * Nutrition and the Environment * Food and Nutrition Education * Nutrition and Economics Research papers on food chemistry (focus on chemical composition and analysis of foods) are generally not considered eligible, unless the results have a clear impact on human nutrition. The journal focuses on the different aspects of nutrition for people involved in nutrition research such as Dentists, Dieticians, Medical doctors, Nutritionists, Teachers, Journalists and Manufacturers in the food and pharmaceutical industries.