The role of epigenetics in hypertension of children and adolescents: a systematic review.

IF 2.3 4区医学

Blood Pressure Pub Date : 2026-12-01 Epub Date: 2025-12-27 DOI:10.1080/08037051.2025.2598105

Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny Nm Soetedjo

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引用次数: 0

Abstract

Aim: This systematic review study aimed to discuss about the possibility role of epigenetic in HTN of children and adolescent.

Material and methods: This evidence-based research is implemented within the scope of the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020. The data were analyzed qualitatively to assess the risk of bias, with the New Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) criteria as the thresholds. Our research highlights in particular showed that there is a role for epigenetics in HTN in children and adolescents.

Conclusion: Fourteen journals were included to be qualitatively assessed. Eleven journals (78.5%) stated that there was a correlation between epigenetic and BP in children and adolescents, however each study examined different genes or loci. In summary, epigenetic modifications of various single nucleotide polymorphisms (SNPs) and other genes were associated with higher systolic and diastolic BP in children and adolescents.

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表观遗传学在儿童和青少年高血压中的作用：一项系统综述。

已知表观遗传修饰有助于高血压的病理生理。只有少数研究全面评估了表观遗传变化对高血压风险的可能作用，特别是在儿童和青少年中。本系统综述研究旨在探讨表观遗传在儿童和青少年高血压中的可能作用。这项基于证据的研究是在2020年系统评价和元分析（PRISMA）首选报告项目的范围内实施的。以新渥太华量表（NOS）和卫生研究与质量局（AHRQ）标准作为阈值，对数据进行定性分析以评估偏倚风险。我们的研究重点特别表明，表观遗传学在儿童和青少年高血压中起着重要作用。纳入14份期刊进行定性评估。11份期刊（78.5%）指出，儿童和青少年的表观遗传与血压之间存在相关性，但每项研究都检测了不同的基因或位点。总之，各种单核苷酸多态性（snp）和其他基因的表观遗传修饰与儿童和青少年较高的收缩压和舒张压相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Pressure Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.20

自引率

5.60%

发文量

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.