Evaluation of the effectiveness of solutions for clearing neonatal central venous catheters: randomized study.

Revista da Escola de Enfermagem da U S P Pub Date : 2025-11-28 eCollection Date: 2025-01-01 DOI:10.1590/1980-220X-REEUSP-2025-0122en

Carolina Mathiolli, Juliane Pagliari Araujo, Keli Regiane Tomeleri da Fonseca Pinto, Rosangela Aparecida Pimenta, Danielle Venturini, Sonia Silva Marcon, Adriana Valongo Zani

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Abstract

Objective: To evaluate the effectiveness of saline, heparin, and vitamin C solutions in unclogging neonatal central venous catheters occluded by clots.

Method: A randomized, double-blind, in vitro experimental study conducted in August 2022 with 90 neonatal central venous catheters occluded with blood that remained in a water bath for 8 hours. The solutions tested were: saline, heparin (50 mg/ml), and vitamin C (25 mg/ml), using a negative pressure technique. The variables of number of attempts and time to unclogging were evaluated in relation to the mean and standard deviation. For variables with abnormal distribution, the Kruskal-Wallis test was used.

Results: There was no statistical significance in relation to the time and number of attempts to unclog the three solutions (p > 0.05), and the maximum time to unclog the catheters was 120 minutes.

Conclusion: The three substances showed similar results. Thus, saline solution is recommended because it is considered safe, with fewer side effects when used in newborns.

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评价新生儿中心静脉导管清除方案的有效性：随机研究。

目的：评价生理盐水、肝素和维生素C溶液对新生儿中心静脉导管血栓阻塞的疏通效果。方法：于2022年8月随机双盲体外实验研究，90例新生儿中心静脉置管被血液堵塞，在水浴中保持8小时。测试的溶液为：生理盐水、肝素（50mg /ml）和维生素C (25mg /ml)，采用负压技术。尝试次数和疏通时间的变量与平均值和标准差进行了评估。对于分布异常的变量，采用Kruskal-Wallis检验。结果：三种溶液的拔管时间、拔管次数比较，差异均无统计学意义（p < 0.05），最长拔管时间为120 min。结论：三种药物的药效相似。因此，建议使用生理盐水溶液，因为它被认为是安全的，在新生儿中使用时副作用更少。

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Revista da Escola de Enfermagem da U S P

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