{"title":"Nutri-epigenetics of mitochondrial function and energy homeostasis in obesity.","authors":"Lydia R Goss, Venkata Saroja Voruganti","doi":"10.1186/s12263-025-00781-w","DOIUrl":null,"url":null,"abstract":"<p><p>Obesity is a multifaceted condition involving complex interactions between genetic and environmental factors. Published studies have reported several genetic loci affecting obesity. Diet, physical activity, and their interaction with genetic variants have been assessed for their role in obesity. However, the role of epigenetic modifications with respect to nutrition, mitochondrial function, and energy homeostasis have not been investigated in depth. This narrative review explores scientific literature and assesses the role of nutrition and epigenetics (Nutri-epigenetics) in energy homeostasis and mitochondrial function and their subsequent effects on obesity. It details how mitochondrial dysfunction, driven by epigenetic changes, contributes to energy imbalance and metabolic disturbances and provides a comprehensive understanding of the underlying mechanisms driving obesity through the lens of the mitochondria and their functions.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":" ","pages":"1"},"PeriodicalIF":2.8000,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12763882/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12263-025-00781-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Obesity is a multifaceted condition involving complex interactions between genetic and environmental factors. Published studies have reported several genetic loci affecting obesity. Diet, physical activity, and their interaction with genetic variants have been assessed for their role in obesity. However, the role of epigenetic modifications with respect to nutrition, mitochondrial function, and energy homeostasis have not been investigated in depth. This narrative review explores scientific literature and assesses the role of nutrition and epigenetics (Nutri-epigenetics) in energy homeostasis and mitochondrial function and their subsequent effects on obesity. It details how mitochondrial dysfunction, driven by epigenetic changes, contributes to energy imbalance and metabolic disturbances and provides a comprehensive understanding of the underlying mechanisms driving obesity through the lens of the mitochondria and their functions.
期刊介绍：
This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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