BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based study.

IF 3.5 4区医学 Q2 UROLOGY & NEPHROLOGY

Therapeutic Advances in Urology Pub Date : 2025-11-25 eCollection Date: 2025-01-01 DOI:10.1177/17562872251397201

Yuwen Zhong, Ganglin Kang, Jing He, Kaimin Xiao, Li Li

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引用次数: 0

Abstract

Objective: This study aimed to further investigate the relationship between the ratio of red cell distribution width to serum albumin (RAR) index and the risk of kidney stones in the US population, focusing on the mediating effect of body mass index (BMI), and to provide new insights into the prevention and management of kidney stone disease.

Methods: This was a cross-sectional study derived from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. The total sample size of the study was 20,755, and the association between RAR and kidney stones was studied using multiple logistic regression, subgroup analysis and mediation analysis.

Results: The findings of this study demonstrate a substantial positive correlation between the prevalence of kidney stones and the RAR index (OR: 1.37, 95% CI: 1.27, 1.49). This association remains consistent even after adjusting for relevant covariates (OR: 1.23, 95% CI: 1.12, 1.36). Utilising curve fitting, threshold effect analysis and restrictive cubic spline methods, an 'S'-shaped non-linear dose-response relationship between the RAR index and the prevalence of kidney stones was identified (p for overall < 0.001, p for non-linear = 0.002). In subgroup analyses, the association between RAR index and the risk of kidney stones was more significant in the obese population (OR: 1.33, 95% CI: 1.18, 1.51, p for interaction = 0.021). The results of the mediation analysis found that BMI played a 24.5% mediating role between the RAR index and kidney stones. Sensitivity analysis also confirmed the stability of this result.

Conclusion: A non-linear association has been identified between the RAR index and the prevalence of kidney stones. The study found that BMI is a mediating variable in this association. In obese individuals of Other Race - Including Multi-Racial, the RAR index has been shown to have a more marked effect on the prevalence of kidney stones.

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BMI介导红细胞分布宽度与血清白蛋白指数和肾结石风险之间的关联：一项基于人群的研究。

目的：本研究旨在进一步探讨美国人群红细胞分布宽度与血清白蛋白（RAR）指数之比与肾结石风险的关系，重点探讨体重指数（BMI）的中介作用，为肾结石疾病的预防和管理提供新的见解。方法：这是一项来自2009-2018年国家健康与营养检查调查（NHANES）的横断面研究。本研究总样本量为20,755人，采用多元logistic回归、亚组分析和中介分析对RAR与肾结石的相关性进行研究。结果：本研究结果表明肾结石患病率与RAR指数之间存在显著正相关（OR: 1.37, 95% CI: 1.27, 1.49）。即使在调整相关协变量后，这种关联仍然是一致的（OR: 1.23, 95% CI: 1.12, 1.36）。利用曲线拟合、阈值效应分析和限制性三次样条方法，确定了RAR指数与肾结石患病率之间的“S”形非线性剂量-反应关系（总体p为非线性p = 0.002）。在亚组分析中，RAR指数与肾结石风险之间的相关性在肥胖人群中更为显著（OR: 1.33, 95% CI: 1.18, 1.51，相互作用p = 0.021）。中介分析结果发现，BMI在RAR指数与肾结石之间起24.5%的中介作用。敏感性分析也证实了该结果的稳定性。结论：RAR指数与肾结石患病率呈非线性关系。研究发现，体重指数是这一关联的中介变量。在其他种族（包括多种族）的肥胖个体中，RAR指数对肾结石的患病率有更显著的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Urology Medicine-Urology

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Therapeutic Advances in Urology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of urology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in urology, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest across all areas of urology, including treatment of urological disorders, with a focus on emerging pharmacological therapies.