Perspectives for artificial intelligence in bioprocess automation

IF 7.8 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Current opinion in biotechnology Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI:10.1016/j.copbio.2025.103392

Laura Marie Helleckes , Sebastian Putz , Kshitiz Gupta , Matthias Franzreb , Hector Garcia Martin

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引用次数: 0

Abstract

Recent advances in artificial intelligence (AI) have rapidly changed the lab automation landscape, promoting self-driving laboratories (SDLs) that enable autonomous scientific discovery. These trends are increasingly applied in bioprocess development, yet bioprocessing faces unique challenges — biological complexity, regulatory and safety requirements, and multiscale experimentation — that distinguish it from other automation domains. Rather than pursuing full autonomy, we foresee that hybrid SDLs, combining AI-driven decision-making with sustained human oversight, represent the most practical near-term trajectory. This review examines three interconnected perspectives: (i) hybrid human–machine decision-making for bioprocessing; (ii) laboratory design considerations in the era of AI; and (iii) scale-up challenges when transitioning from screening to manufacturing. We highlight critical gaps in data standardization and the required community efforts necessary to realize autonomous bioprocess innovation.

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人工智能在生物过程自动化中的应用前景

人工智能（AI）的最新进展迅速改变了实验室自动化的格局，推动了能够自主科学发现的自动驾驶实验室（sdl）的发展。这些趋势越来越多地应用于生物工艺开发，但生物加工面临着独特的挑战-生物复杂性，监管和安全要求，以及多尺度实验-将其与其他自动化领域区分开来。我们预计，混合sdl（将人工智能驱动的决策与持续的人类监督相结合）将代表最实用的近期发展轨迹，而不是追求完全自主。本文综述了三个相互关联的观点：(i)生物加工的混合人机决策；（ii）人工智能时代的实验室设计考量；（三）从筛选过渡到生产时的规模挑战。我们强调了数据标准化方面的关键差距，以及实现自主生物工艺创新所需的社区努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.